Belibasakis, GN, Ozturk, VO, Emingil, G, Bostanci, N. 2014. Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in gingival crevicular fluid: association with clinical and microbiologic parameters. J Periodontol. 85(1):204–210.
Google Scholar | Crossref | Medline Benoit, M, Desnues, B, Mege, JL. 2008. Macrophage polarization in bacterial infections. J Immunol. 181(6):3733–3739.
Google Scholar | Crossref | Medline | ISI Bisson, C, Massin, F, Lefevre, PA, Thilly, N, Miller, N, Gibot, S. 2012. Increased gingival crevicular fluid levels of soluble triggering receptor expressed on myeloid cells (sTREM)-1 in severe periodontitis. J Clin Periodontol. 39(12):1141–1148.
Google Scholar | Crossref | Medline Bostanci, N, Abe, T, Belibasakis, GN, Hajishengallis, G. 2019. TREM-1 is upregulated in experimental periodontitis, and its blockade inhibits IL-17A and RANKL expression and suppresses bone loss. J Clin Med. 8(10):1579.
Google Scholar | Crossref | Medline Bouchon, A, Dietrich, J, Colonna, M. 2000. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 164(10):4991–4995.
Google Scholar | Crossref | Medline | ISI Chen, LC, Laskin, JD, Gordon, MK, Laskin, DL. 2008. Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. Exp Mol Pathol. 84(2):145–155.
Google Scholar | Crossref | Medline Chen, SS, Wang, K, Zhao, J, Wu, WC, Wu, YF, Zhao, L. 2017. Increased expression of triggering receptor expressed on myeloid cells 1 and 2 in inflamed human gingiva. J Periodontal Res. 52(3):512–521.
Google Scholar | Crossref | Medline Derive, M, Gibot, S. 2011. Urine sTREM-1 assessment in diagnosing sepsis and sepsis-related acute kidney injury. Crit Care. 15(6):1013.
Google Scholar | Crossref | Medline Fan, D, He, X, Bian, Y, Guo, Q, Zheng, K, Zhao, Y, Lu, C, Liu, B, Xu, X, Zhang, G, et al. 2016. Triptolide modulates TREM-1 signal pathway to inhibit the inflammatory response in rheumatoid arthritis. Int J Mol Sci. 17(4):498.
Google Scholar | Crossref | Medline Feng, Z, Weinberg, A. 2006. Role of bacteria in health and disease of periodontal tissues. Periodontol 2000. 40:50–76.
Google Scholar | Crossref Friedman, PK, Lamster, IB. 2016. Tooth loss as a predictor of shortened longevity: exploring the hypothesis. Periodontol 2000. 72(1):142–152.
Google Scholar | Crossref | Medline Hajishengallis, G . 2020. New developments in neutrophil biology and periodontitis. Periodontol 2000. 82(1):78–92.
Google Scholar | Crossref | Medline Hasturk, H, Kantarci, A, Van Dyke, TE. 2012. Oral inflammatory diseases and systemic inflammation: role of the macrophage. Front Immunol. 3:118.
Google Scholar | Crossref | Medline | ISI Hu, X, Chen, J, Wang, L, Ivashkiv, LB. 2007. Crosstalk among JAK-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation.J Leukoc Biol. 82(2):237–243.
Google Scholar | Crossref | Medline Kim, D, Langmead, B, Salzberg, SL. 2015. HISAT: a fast spliced aligner with low memory requirements. Nat Methods. 12(4):357–360.
Google Scholar | Crossref | Medline | ISI Kozik, JH, Trautmann, T, Carambia, A, Preti, M, Lutgehetmann, M, Krech, T, Wiegard, C, Heeren, J, Herkel, J. 2016. Attenuated viral hepatitis in TREM1-/- mice is associated with reduced inflammatory activity of neutrophils. Sci Rep. 6:28556.
Google Scholar | Crossref | Medline Liang, S, Domon, H, Hosur, KB, Wang, M, Hajishengallis, G. 2009. Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro. Mech Ageing Dev. 130(8):538–546.
Google Scholar | Crossref | Medline Lin, SH, Chuang, HY, Ho, JC, Lee, CH, Hsiao, CC. 2018. Treatment with TNF-α inhibitor rectifies M1 macrophage polarization from blood CD14+ monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation. J Dermatol Sci. 91(3):276–284.
Google Scholar | Crossref | Medline Mosser, DM, Edwards, JP. 2008. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 8(12):958–969.
Google Scholar | Crossref | Medline | ISI Murray, PJ . 2007. The JAK-STAT signaling pathway: input and output integration. J Immunol. 178(5):2623–2629.
Google Scholar | Crossref | Medline | ISI Pelham, CJ, Pandya, AN, Agrawal, DK. 2014. Triggering receptor expressed on myeloid cells receptor family modulators: a patent review. Expert Opin Ther Pat. 24(12):1383–1395.
Google Scholar | Crossref | Medline Qin, H, Holdbrooks, AT, Liu, Y, Reynolds, SL, Yanagisawa, LL, Benveniste, EN. 2012. SOCS3 deficiency promotes M1 macrophage polarization and inflammation. J Immunol. 189(7):3439–3448.
Google Scholar | Crossref | Medline Rauch, I, Muller, M, Decker, T. 2013. The regulation of inflammation by interferons and their stats. JAKSTAT. 2(1):e23820.
Google Scholar | Medline Shi, C, Pamer, EG. 2011. Monocyte recruitment during infection and inflammation. Nat Rev Immunol. 11(11):762–774.
Google Scholar | Crossref | Medline | ISI Sima, C, Glogauer, M. 2013. Macrophage subsets and osteoimmunology: tuning of the immunological recognition and effector systems that maintain alveolar bone. Periodontol 2000. 63(1):80–101.
Google Scholar | Crossref | ISI Subramanian, A, Tamayo, P, Mootha, VK, Mukherjee, S, Ebert, BL, Gillette, MA, Paulovich, A, Pomeroy, SL, Golub, TR, Lander, ES, et al. 2005. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 102(43):15545–15550.
Google Scholar | Crossref | Medline | ISI Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, et al. 2013. Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature. 496(7444):238–242.
Google Scholar | Crossref | Medline Tompkins, KA . 2016. The osteoimmunology of alveolar bone loss. Connect Tissue Res. 57(2):69–90.
Google Scholar | Crossref | Medline Viniegra, A, Goldberg, H, Cil, C, Fine, N, Sheikh, Z, Galli, M, Freire, M, Wang, Y, Van Dyke, TE, Glogauer, M, et al. 2018. Resolving macrophages counter osteolysis by anabolic actions on bone cells. J Dent Res. 97(10):1160–1169.
Google Scholar | SAGE Journals | ISI Weng, Y, Wang, H, Li, L, Feng, Y, Xu, S, Wang, Z. 2021. Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment. Redox Biol. 40:101849.
Google Scholar | Crossref | Medline Willi, M, Belibasakis, GN, Bostanci, N. 2014. Expression and regulation of triggering receptor expressed on myeloid cells 1 in periodontal diseases. Clin Exp Immunol. 178(1):190–200.
Google Scholar | Crossref | Medline Wu, X, Chen, H, Wang, Y, Gu, Y. 2020. Akt2 affects periodontal inflammation via altering the M1/M2 ratio. J Dent Res. 99(5):577–587.
Google Scholar | SAGE Journals | ISI Yang, J, Zhu, Y, Duan, D, Wang, P, Xin, Y, Bai, L, Liu, Y, Xu, Y. 2018. Enhanced activity of macrophage M1/M2 phenotypes in periodontitis. Arch Oral Biol. 96:234–242.
Google Scholar | Crossref | Medline Yu, T, Zhao, L, Huang, X, Ma, C, Wang, Y, Zhang, J, Xuan, D. 2016. Enhanced activity of the macrophage M1/M2 phenotypes and phenotypic switch to M1 in periodontal infection. J Periodontol. 87(9):1092–1102.
Google Scholar | Crossref | Medline Zhao, FL, Qin, CF. 2019. EGF promotes HIF-1α expression in colorectal cancer cells and tumor metastasis by regulating phosphorylation of STAT3. Eur Rev Med Pharmacol Sci. 23(3):1055–1062.
Google Scholar | Medline Zhou, D, Huang, C, Lin, Z, Zhan, S, Kong, L, Fang, C, Li, J. 2014. Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways. Cell Signal. 26(2):192–197.
Google Scholar | Crossref | Medline Zhou, LN, Bi, CS, Gao, LN, An, Y, Chen, F, Chen, FM. 2019. Macrophage polarization in human gingival tissue in response to periodontal disease. Oral Dis. 25(1):265–273.
Google Scholar | Crossref | Medline Zhuang, Z, Yoshizawa-Smith, S, Glowacki, A, Maltos, K, Pacheco, C, Shehabeldin, M, Mulkeen, M, Myers, N, Chong, R, Verdelis, K, et al. 2019. Induction of M2 macrophages prevents bone loss in murine periodontitis models. J Dent Res. 98(2):200–208.
Google Scholar | SAGE Journals | ISI Zong, Z, Zou, J, Mao, R, Ma, C, Li, N, Wang, J, Wang, X, Zhou, H, Zhang, L, Shi, Y. 2019. M1 macrophages induce PD-L1 expression in hepatocellular carcinoma cells through IL-1β signaling. Front Immunol. 10:1643.
Google Scholar | Crossref