Aloe barbadensis Mill. extract improves symptoms in IBS patients with diarrhoea: post hoc analysis of two randomized double-blind controlled studies

1. Lacy, BE, Pimentel, M, Brenner, DM, et al. ACG clinical guideline: management of irritable bowel syndrome. Am J Gastroenterol 2021; 116: 17–44.
Google Scholar | Crossref | Medline2. Sperber, AD, Dumitrascu, D, Fukudo, S, et al. The global prevalence of IBS in adults remains elusive due to the heterogeneity of studies: a Rome Foundation working team literature review. Gut 2017; 66: 1075–1082.
Google Scholar | Crossref | Medline3. Simren, M, Tack, J. New treatments and therapeutic targets for IBS and other functional bowel disorders. Nat Rev Gastroenterol Hepatol 2018; 15: 589–605.
Google Scholar | Crossref | Medline4. Engsbro, AL, Simren, M, Bytzer, P. Short-term stability of subtypes in the irritable bowel syndrome: prospective evaluation using the Rome III classification. Aliment Pharmacol Ther 2012; 35: 350–359.
Google Scholar | Crossref | Medline5. Hussain, Z, Quigley, EM. Systematic review: complementary and alternative medicine in the irritable bowel syndrome. Aliment Pharmacol Ther 2006; 23: 465–471.
Google Scholar | Crossref | Medline6. Magge, S, Lembo, A. Complementary and alternative medicine for the irritable bowel syndrome. Gastroenterol Clin North Am 2011; 40: 245–253.
Google Scholar | Crossref | Medline7. Bahrami, HR, Hamedi, S, Salari, R, et al. Herbal medicines for the management of irritable bowel syndrome: a systematic review. Electron Physician 2016; 8: 2719–2725.
Google Scholar | Crossref | Medline8. Nguyen, L. Complementary and alternative medicine for the management of irritable bowel syndrome. Gastroenterol Hepatol (N Y) 2018; 14: 536–538.
Google Scholar | Medline9. Rodriguez, ER, Martin, JD, Romero, CD. Aloe vera as a functional ingredient in foods. Crit Rev Food Sci Nutr 2010; 50: 305–326.
Google Scholar | Crossref | Medline10. Sánchez, M, González-Burgos, E, Iglesias, I, et al. Pharmacological update properties of Aloe vera and its major active constituents. Molecules 2020; 6: 1324.
Google Scholar11. Davis, K, Philpott, S, Kumar, D, et al. Randomised double-blind placebo-controlled trial of aloe vera for irritable bowel syndrome. Int J Clin Pract 2006; 60: 1080–1086.
Google Scholar | Crossref | Medline12. Khedmat, H, Karbasi, A, Amini, M, et al. Aloe vera in treatment of refractory irritable bowel syndrome: trial on Iranian patients. J Res Med Sci 2013; 18: 732.
Google Scholar | Medline13. Ahluwalia, B, Magnusson, MK, Bohn, L, et al. Randomized clinical trial: effects of Aloe barbadensis Mill. extract on symptoms, fecal microbiota and fecal metabolite profiles in patients with irritable bowel syndrome. Neurogastroenterol Motil 2020; 32; e13860.
Google Scholar | Crossref | Medline14. Storsrud, S, Ponten, I, Simren, M. A pilot study of the effect of Aloe barbadensis Mill. extract (AVH200(R)) in patients with irritable bowel syndrome: a randomized, double-blind, placebo-controlled study. J Gastrointestin Liver Dis 2015; 24: 275–280.
Google Scholar | Crossref | Medline15. Hutchings, HA, Wareham, K, Baxter, JN, et al. A randomised, cross-over, placebo-controlled study of Aloe vera in patients with irritable bowel syndrome: effects on patient quality of life. ISRN Gastroenterol 2011; 2011: 206103.
Google Scholar | Crossref | Medline16. Longstreth, GF, Thompson, WG, Chey, WD, et al. Functional bowel disorders. Gastroenterology 2006; 130: 1480–1491.
Google Scholar | Crossref | Medline | ISI17. Francis, CY, Morris, J, Whorwell, PJ. The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Aliment Pharmacol Ther 1997; 11: 395–402.
Google Scholar | Crossref | Medline | ISI18. Heaton, KW, O’Donnell, LJ. An office guide to whole-gut transit time. Patients’ recollection of their stool form. J Clin Gastroenterol 1994; 19: 28–30.
Google Scholar | Crossref | Medline | ISI19. Zigmond, AS, Snaith, RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67: 361–370.
Google Scholar | Crossref | Medline | ISI20. Zhang, J, Yu, KF. What’s the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. JAMA 1998; 280: 1690–1691.
Google Scholar | Crossref | Medline | ISI21. Bjelland, I, Dahl, AA, Haug, TT, et al. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res 2002; 52: 69–77.
Google Scholar | Crossref | Medline | ISI22. Mearin, F, Lacy, BE, Chang, L, et al. Bowel disorders. Gastroenterology. Epub ahead of print 18 February 2016. DOI: 10.1053/j.gastro.2016.02.031.
Google Scholar | Crossref23. Lacy, BE, Patel, NK. Rome criteria and a diagnostic approach to irritable bowel syndrome. J Clin Med 2017; 6: 99.
Google Scholar | Crossref | Medline24. Spiegel, B, Strickland, A, Naliboff, BD, et al. Predictors of patient-assessed illness severity in irritable bowel syndrome. Am J Gastroenterol 2008; 103: 2536–2543.
Google Scholar | Crossref | Medline | ISI25. Drossman, DA, Morris, CB, Schneck, S, et al. International survey of patients with IBS: symptom features and their severity, health status, treatments, and risk taking to achieve clinical benefit. J Clin Gastroenterol 2009; 43: 541–550.
Google Scholar | Crossref | Medline | ISI26. Palsson, OS, Baggish, J, Whitehead, WE. Episodic nature of symptoms in irritable bowel syndrome. Am J Gastroenterol 2014; 109: 1450–1460.
Google Scholar | Crossref | Medline | ISI27. Houghton, LA, Heitkemper, M, Crowell, M, et al. Age, gender and women’s health and the patient. Gastroenterology. Epub ahead of print 15 February 2016. DOI: 10.1053/j.gastro.2016.02.017.
Google Scholar | Crossref28. Ouyang, A, Wrzos, HF. Contribution of gender to pathophysiology and clinical presentation of IBS: should management be different in women? Am J Gastroenterol 2006; 101: S602–S609.
Google Scholar | Medline29. Kim, YS, Kim, N. Sex-gender differences in irritable bowel syndrome. J Neurogastroenterol Motil 2018; 24: 544–558.
Google Scholar | Crossref | Medline30. European Medicines Agency . European Union herbal monograph on Aloe barbadensis Mill. and on Aloe (various species, mainly Aloe ferox Mill. and its hybrids), folii succus siccatus. In: Products Committee on Herbal Medicinal Products. United Kingdom: European Medicines Agency, 2016, pp. 3–4.
Google Scholar31. Ahluwalia, B, Magnusson, MK, Isaksson, S, et al. Effects of Aloe barbadensis Mill. Extract (AVH200(R)) on human blood T cell activity in vitro. J Ethnopharmacol 2016; 179: 301–309.
Google Scholar | Crossref | Medline32. Davis, RH, Donato, JJ, Hartman, GM, et al. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. J Am Podiatr Med Assoc 1994; 84: 77–81.
Google Scholar | Crossref | Medline33. Gullon, B, Gullon, P, Tavaria, F, et al. In vitro assessment of the prebiotic potential of Aloe vera mucilage and its impact on the human microbiota. Food Funct 2015; 6: 525–531.
Google Scholar | Crossref | Medline34. Shah, ED, Almario, CV, Spiegel, BM, et al. Presentation and characteristics of abdominal pain vary by irritable bowel syndrome subtype: results of a nationwide population-based study. Am J Gastroenterol 2020; 115: 294–301. DOI: 10.14309/ajg.0000000000000502.
Google Scholar | Crossref | Medline35. Ahluwalia, B, Iribarren, C, Magnusson, MK, et al. A distinct faecal microbiota and metabolite profile linked to bowel habits in patients with irritable bowel syndrome. Cells 2021; 10: 1459.
Google Scholar | Crossref36. Bouhnik, Y, Raskine, L, Champion, K, et al. Prolonged administration of low-dose inulin stimulates the growth of bifidobacteria in humans. Nutr Res 2007; 27: 187–193.
Google Scholar | Crossref37. Closa-Monasterolo, R, Ferre, N, Castillejo-DeVillasante, G, et al. The use of inulin-type fructans improves stool consistency in constipated children. A randomised clinical trial: pilot study. Int J Food Sci Nutr 2017; 68: 587–594.
Google Scholar | Crossref | Medline38. Meyer, D, Stasse-Wolthuis, M. The bifidogenic effect of inulin and oligofructose and its consequences for gut health. Eur J Clin Nutr 2009; 63: 1277–1289.
Google Scholar | Crossref | Medline39. Jones, J, Lembo, A, Heidelbaugh, J, et al. Management of irritable bowel syndrome with diarrhea: focus on eluxadoline. Curr Med Res Opin 2021; 37: 567–578.
Google Scholar | Crossref | Medline

Comments (0)

No login
gif