G.S.-H. and M.F. contributed equally to this work.

Current address of G.S.-H., Thermo Fisher Scientific, Av. Marathon 1315, Ñuñoa, Santiago, Chile; of M.F., Roche Diagnóstica, Av. Cerro el Plomo 5660, Las Condes, Santiago, Chile; of P.P., NIDCR, National Institute of Health, 9000 Rockville Pike, Bldg 10, Room 1A01, Bethesda, MD; of J.C., Kura Biotec, Av. Gramado (interior) #s/n, Parcelación Neumann, Puerto Varas, Chile; and of M.G.deA., Thermo Fisher Scientific, Rua Eugênio de Medeiros 303, Pinheiros, São Paulo, SP, Brazil.

FUNDING

This work received support from Chilean Government CORFO-International Center of Excellence Program (Grant # 13CEE2-21602) and Thermo Fisher Scientific. The funding sources were not involved in the study design, the collection, analysis, and interpretation of data; in the writing of the report, neither in the decision to submit the article for publication.

CONFLICT OF INTEREST STATEMENT

G.S., M.F., R.A., R.A.C., A.B., L.R., D.A., R.L., J.C. and P.P. were CEMP Pfizer Chile employees. H.F., E.D.N., D.N.N., G.P.B., M.G.A., C.F., G.B., J.F., S.C., O.A., M.L.S., G.R., C.S., K.M. and S.R. received a grant and non-financial support to perform this work for CEMP Pfizer Chile. Outside this work, H.F. discloses personal fees and non-financial support from Pfizer and BMS and non-financial support from AstraZeneca and Roche.

Author Contributions

1. Conceptualization: Matías Freire, Gonzalo Sepúlveda-Hermosilla, Sara Chernilo, Cristina Fernández, Emmanuel Dias-Neto, Helano Freitas, Paola Pérez and Ricardo Armisén.

2. Data acquisition and curation: Gonzalo Sepúlveda-Hermosilla, Matías Freire, Alejandro Blanco, Carolina Sánchez, Cristina Fernández, Diana Noronha Nunes, Diego Ampuero, Emmanuel Dias-Neto, Germán Rasse, Giuliano Bernal, Jacqueline Flores, Helano Freitas, Javier Cáceres, Katherine Marcelain, Liliana Ramos, Maria Galli de Amorim, Gabriela Pereira Branco, María Loreto Spencer, Osvaldo Aren, Rodrigo Lizana, Sara Chernilo, Solange Rivas and Paola Pérez, Rodrigo Assar, Ricardo Armisén.

3. Formal analyses: Gonzalo Sepúlveda-Hermosilla, Alejandro Blanco, Javier Cáceres, Paola Pérez, Rodrigo Assar and Ricardo Armisén.

4. Methodology: Paola Pérez, Gonzalo Sepúlveda-Hermosilla, Rodrigo Assar and Ricardo Armisén.

5. Writing – original draft: Gonzalo Sepulveda-Hermosilla, Matias Freire, Paola Pérez and Ricardo Armisén.

6. Writing – review & editing: all co-authors and Ricardo Armisén.

R.A. is the guarantor of this work and, as such, has full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.