Basic Thyroidology / Research Article

Rinaldini E.a· Verde Arboccó F.C.a· Ezquer M.b· Gamarra-Luques C.a,c· Hapon M.B.a,d

Author affiliations

aConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Mendoza, Argentina
bCentro de Medicina Regenerativa, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile
cFacultad de Ciencias Médicas, Instituto de Fisiología, Universidad Nacional de Cuyo, Mendoza, Argentina
dFacultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, Mendoza, Argentina

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Article / Publication Details

First-Page Preview

Received: December 03, 2020
Accepted: April 08, 2021
Published online: May 27, 2021

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 0

ISSN: 2235-0640 (Print)
eISSN: 2235-0802 (Online)

For additional information: https://www.karger.com/ETJ

Abstract

Introduction: The potential of the thyroid hormone receptor β (TRβ1) selective analog GC-1 has been widely proven in animal models and humans. However, its effect on the reproductive stage of the female rat has not been evaluated. Methods: The effect of the administration of GC-1 or equimolar doses of triiodothyronine (T3) was evaluated on the reproductive performance of the hypothyroid female rat and the indirect effect on pup thyroid status, weight, and survival. Results: Hypothyroidism reduced the number of embryos implanted in the uterus, whereas T3 and GC-1 treatment in hypothyroid females reestablished the number of implanted embryos to normal. Initiation of labor was delayed by hypothyroidism, and T3 replacement treatment reinstated the normal timing of parturition. The administration of GC-1 alone to the lactating mother did not affect pup survival, weight, or thyroidal status. Conclusions: Our findings show the differential effect of thyroid hormone selective signaling during gestation and the indirect exposure of the pups; we also emphasize the plausible use of GC-1 for treatment of hypothyroid mothers during the lactation period.

© 2021 European Thyroid Association Published by S. Karger AG, Basel

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First-Page Preview

Received: December 03, 2020
Accepted: April 08, 2021
Published online: May 27, 2021

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 0

ISSN: 2235-0640 (Print)
eISSN: 2235-0802 (Online)

For additional information: https://www.karger.com/ETJ

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