We thank the participants for contributing their samples for our study. We also acknowledge the support from the High-performance Computing Platform of Peking University.

This study received support from the following grants: the Natural Science Foundation of Beijing Municipality (7242149, L202034, 7244416), the E-Town Cooperation & Development Foundation (YCXJ-JZ-2023-017), the National Natural Science Foundation of China (82171694, 81901155), National High Level Hospital Clinical Research