Data were collected from the medical records before and at 1, 2, and 3 years after initiation of GH treatment. The collected data included chronological age (CA), sex, auxological parameters (Ht, Wt, BMI), pubertal staging, GH dose, and IGF-1 levels.

Ht was measured with a Harpenden stadiometer (Holtain Ltd, Crosswell, UK) and Wt with a calibrated scale. BMI was calculated as Wt (kg) divided by Ht (m) squared. Ht, Wt, and BMI were expressed as SDS according to the recommendations of the Centers