Available online 5 August 2025, 102043

The heterogeneous implementation of colorectal cancer screening programs across Europe makes performance comparison challenging.

This study computed and analyzed seven key indicators of screening performance for eighteen European programs between 2011 and 2022. Trends in colorectal cancer incidence and mortality were also examined in relation to when each screening program was introduced.

Coverage indicators showed considerable variation across programs but generally increased until the onset of the COVID pandemic. Yield indicators remained stable overall, whereas jumps were associated to protocol changes. In most countries, a decline in incidence followed the introduction of the screening program, whereas the connection of screening with mortality was less evident.

The analysis of comparable screening performance indicators over time allows for cross-country and longitudinal monitoring of the programs. The observed decline in incidence following the implementation of fully rolled-out programs highlights the importance and effectiveness of well-organized screening in reducing the burden of the disease.

Colorectal cancer

Screening performance indicators

European screening programs

Incidence

Mortality

Trends

© 2025 The Authors. Published by Elsevier Ltd.