Human rhinovirus (HRV), a single-stranded, positive-sense RNA virus that belongs to the family Picornaviridae, consists of more than 100 serotypes and is classified into three species (HRV-A, B, and C) [1]. HRV is widely recognized as a major pathogen associated with a common cold, however recent studies show that this virus has also been involved in asthma exacerbation and pneumonia with severity comparable to that of other respiratory viruses [2,3]. The emergence of severe acute respiratory virus 2 (SARS-CoV-2) has impacted the epidemics of respiratory viruses by multiple factors including social measures and viral interference [4,5]. The impact varies from virus to virus. Notably, surgical face masks have been reported to substantially reduce the detection of influenza virus (IFV) and seasonal coronavirus (CoV) in droplets and aerosols, while demonstrating little effect on HRV [6]. Furthermore, ethanol disinfectant exhibited virucidal activity against most respiratory viruses, however it is ineffective to non-enveloped viruses including HRV [7]. Epidemiological studies corroborated these findings, indicating that HRV was still detected during coronavirus disease 2019 (COVID-19) pandemic in contrast to the marked decline of other respiratory viruses such as IFV [4,8]. This phenomenon was also observed in the hospital settings; the detection rate of HRV alone was not reduced even with optimized infection control measures [9]. Therefore, HRV cannot be underestimated and special attention should be paid to this virus even in the COVID-19 era. Here, we report a case of nosocomial outbreak of HRV-A34 occurred in a long-term care facility in Okinawa, Japan, with literature review.