Klein NP, Bartlett J, Fireman B, Marks MA, Hansen J, Lewis E. Effectiveness of the live zoster vaccine during the 10 years following vaccination: Real world cohort study using electronic health records. BMJ 2023, 383: e076321.

Article  PubMed  PubMed Central  Google Scholar 

Frezel N, Ranucci M, Foster E, Wende H, Pelczar P, Mendes R, et al. C-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy. Cell Rep 2023, 42: 112295.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Melzack R, Wall PD. Pain mechanisms: A new theory. Science 1965, 150: 971–979.

Article  CAS  PubMed  Google Scholar 

Braz J, Solorzano C, Wang X, Basbaum AI. Transmitting pain and itch messages: A contemporary view of the spinal cord circuits that generate gate control. Neuron 2014, 82: 522–536.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peirs C, Dallel R, Todd AJ. Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia. J Neural Transm (Vienna) 2020, 127: 505–525.

Article  PubMed  Google Scholar 

Artola A, Voisin D, Dallel R. PKCγ interneurons, a gateway to pathological pain in the dorsal horn. J Neural Transm (Vienna) 2020, 127: 527–540.

Article  CAS  PubMed  Google Scholar 

Nelson TS. Dorsal horn PKCγ interneurons mediate mechanical allodynia through 5-HT2AR-dependent structural reorganization. J Neurosci 2019, 39: 6221–6223.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alba-Delgado C, Mountadem S, Mermet-Joret N, Monconduit L, Dallel R, Artola A, et al. 5-HT2A receptor-induced morphological reorganization of PKCγ-expressing interneurons gates inflammatory mechanical allodynia in rat. J Neurosci 2018, 38: 10489–10504.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou XL, Zhang CJ, Wang Y, Wang M, Sun LH, Yu LN, et al. EphrinB-EphB signaling regulates spinal pain processing via PKCgamma. Neurosci 2015, 307: 64–72.

Article  CAS  Google Scholar 

Miletic G, Hermes JL, Bosscher GL, Meier BM, Miletic V. Protein kinase C gamma-mediated phosphorylation of GluA1 in the postsynaptic density of spinal dorsal horn neurons accompanies neuropathic pain, and dephosphorylation by calcineurin is associated with prolonged analgesia. Pain 2015, 156: 2514–2520.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aira Z, Buesa I, García Del Caño G, Bilbao J, Doñate F, Zimmermann M, et al. Transient, 5-HT2B receptor-mediated facilitation in neuropathic pain: Up-regulation of PKCγ and engagement of the NMDA receptor in dorsal horn neurons. Pain 2013, 154: 1865–1877.

Article  CAS  PubMed  Google Scholar 

Wang Q, Zhang X, He X, Du S, Jiang Z, Liu P, et al. Synaptic dynamics of the feed-forward inhibitory circuitry gating mechanical allodynia in mice. Anesthesiology 2020, 132: 1212–1228.

Article  CAS  PubMed  Google Scholar 

Huang J, Gadotti VM, Chen L, Souza IA, Huang S, Wang D, et al. A neuronal circuit for activating descending modulation of neuropathic pain. Nat Neurosci 2019, 22: 1659–1668.

Article  CAS  PubMed  Google Scholar 

Dieb W, Ouachikh O, Alves S, Boucher Y, Durif F, Hafidi A. Nigrostriatal dopaminergic depletion increases static orofacial allodynia. J Headache Pain 2016, 17: 11.

Article  PubMed  PubMed Central  Google Scholar 

Chen Q, Heinricher MM. Descending control mechanisms and chronic pain. Curr Rheumatol Rep 2019, 21: 13.

Article  PubMed  Google Scholar 

Ossipov MH, Dussor GO, Porreca F. Central modulation of pain. J Clin Invest 2010, 120: 3779–3787.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuner R, Kuner T. Cellular circuits in the brain and their modulation in acute and chronic pain. Physiol Rev 2021, 101: 213–258.

Article  CAS  PubMed  Google Scholar 

Obata H. Analgesic mechanisms of antidepressants for neuropathic pain. Int J Mol Sci 2017, 18: 2483.

Article  PubMed  PubMed Central  Google Scholar 

Sasaki M, Kamiya Y, Bamba K, Onishi T, Matsuda K, Kohno T, et al. Serotonin plays a key role in the development of opioid-induced hyperalgesia in mice. J Pain 2021, 22: 715–729.

Article  CAS  PubMed  Google Scholar 

Heijmans L, Mons MR, Joosten EA. A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation. Mol Pain 2021, 17: 17448069211043964.

Article  CAS  PubMed  PubMed Central  Google Scholar 

François A, Low SA, Sypek EI, Christensen AJ, Sotoudeh C, Beier KT, et al. A brainstem-spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins. Neuron 2017, 93: 822-839.e6.

Article  PubMed  PubMed Central  Google Scholar 

Ye DW, Liu C, Liu TT, Tian XB, Xiang HB. Motor cortex-periaqueductal gray-spinal cord neuronal circuitry may involve in modulation of nociception: A virally mediated transsynaptic tracing study in spinally transected transgenic mouse model. PLoS One 2014, 9: e89486.

Article  PubMed  PubMed Central  Google Scholar 

Guo F, Du Y, Qu FH, Lin SD, Chen Z, Zhang SH. Dissecting the neural circuitry for pain modulation and chronic pain: Insights from optogenetics. Neurosci Bull 2022, 38: 440–452.

Article  PubMed  PubMed Central  Google Scholar 

Aira Z, Buesa I, Gallego M, García del Caño G, Mendiable N, Mingo J, et al. Time-dependent cross talk between spinal serotonin 5-HT2A receptor and mGluR1 subserves spinal hyperexcitability and neuropathic pain after nerve injury. J Neurosci 2012, 32: 13568–13581.

Kim YS, Chu Y, Han L, Li M, Li Z, LaVinka PC, et al. Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain. Neuron 2014, 81: 873–887.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He X, Liu P, Zhang X, Jiang Z, Gu N, Wang Q, et al. Molecular and electrophysiological characterization of dorsal horn neurons in a GlyT2-iCre-tdTomato mouse line. J Pain Res 2021, 14: 907–921.

Article  PubMed  PubMed Central  Google Scholar 

Zhang X, Liu P, He X, Jiang Z, Wang Q, Gu N, et al. The PKCγ neurons in anterior cingulate cortex contribute to the development of neuropathic allodynia and pain-related emotion. Mol Pain 2021, 17: 17448069211061972.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988, 33: 87–107.

Article  PubMed  Google Scholar 

Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994, 53: 55–63.

Article  CAS  PubMed  Google Scholar 

Bakkum DJ, Frey U, Radivojevic M, Russell TL, Müller J, Fiscella M, et al. Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites. Nat Commun 2013, 4: 2181.

Article  PubMed  Google Scholar 

Sullivan SJ, Sdrulla AD. Excitatory and inhibitory neurons of the spinal cord superficial dorsal horn diverge in their somatosensory responses and plasticity in vivo. J Neurosci 2022, 42: 1958–1973.

Article  CAS