Diagnosis and treatment of male urethral condyloma acuminata (MUCA) pose a major challenge in clinical practice due idden and special anatomical structure.

Thulium laser is superior in preventing urethral strictures, compared with the holmium lase.

We used a self-made injector from a ureteral catheter to make the 5-aminolevulinic acid (ALA) gel reach the treatment depth in the urethra. By modifying the conventional PDT approach, we obtained a better therapeutic outcome.

Photodynamic therapy combined with thulium laser achieved effective treatment of MUCA.

Condyloma acuminata (CA) is one of the most common sexually transmitted diseases caused by human papillomavirus (HPV) infection. 5-aminolevulinic acid (ALA)-based photodynamic therapy has shown good efficacy in the treatment of HPV-related diseases . In recent years, the incidence of male urethral condyloma acuminata (MUCA) has been gradually increasing. However, due to its hidden and special anatomical structure, diagnosis and treatment pose a major challenge in clinical practice. In this report, photodynamic therapy combined with thulium laser achieved a sufficient effect on MUCA. We made an injector modifying a ureteral catheter to make the 5-aminolevulinic acid (ALA) gel reach the treatment depth in the urethra. And there was no recurrence during the 2-year follow-up period.

HPV

Condyloma acuminata

Photodynamic therapy

5-ALA

Case report

© 2025 The Author(s). Published by Elsevier B.V.