Hemi-epiphysiodesis, or implant-mediated guided growth (IMGG), is a common and effective operation used to treat angular deformities about the knee in children with at least 2 years of skeletal growth remaining. There are several pathologies associated with coronal malalignment of the knee, including patellofemoral instability (PFI), osteochondritis dissecans (OCD), anterior cruciate ligament (ACL) tears, and meniscus injuries. In skeletally immature patients with PFI and genu valgum, simultaneous medial patellofemoral ligament reconstruction (MPFL) and IMGG has demonstrated successful outcomes with low rates of recurrent instability. Furthermore, young patients with OCD lesions can be treated with hemi-epiphysiodesis to unload the affected medial or lateral compartment of the knee. Finally, as genu valgum puts more stress on the ACL and lateral meniscus, IMGG may lead to improved outcomes after ACL reconstruction and lateral discoid meniscus saucerization.