Rawlings DJ, Witte ON (1994) Bruton’s tyrosine kinase is a key regulator in B-cell development. Immunol Rev 138(1):105–119. https://doi.org/10.1111/j.1600-065X.1994.tb00849.x
Article CAS PubMed Google Scholar
Smith CI, Islam TC, Mattsson PT, Mohamed AJ, Nore BF, Vihinen M (2001) The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species, BioEssays News Rev. Mol Cell Dev Biol 23(5):436–446. https://doi.org/10.1002/bies.1062
Wu H et al (2014) Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma. ACS Chem Biol 9(5):1086–1091. https://doi.org/10.1021/cb4008524
Article CAS PubMed PubMed Central Google Scholar
Hagemann T., Kwan SP. (1993) A BstNI polymorphism at the BTK locus in Xq21.3 – Xq22 Hum Mol Genet. 2(12):2201. https://doi.org/10.1093/hmg/2.12.2201.
Vetrie D et al (1993) The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature 361(6409):226–233. https://doi.org/10.1038/361226a0
Article CAS PubMed Google Scholar
Bruton OC (1952) Agammaglobulinemia. Pediatrics 9(6):722–728. https://doi.org/10.1542/peds.9.6.722
Article CAS PubMed Google Scholar
Suri D, Rawat A, Singh S (2016) X-linked agammaglobulinemia. Indian J Pediatr 83(4):331–337. https://doi.org/10.1007/s12098-015-2024-8
Väliaho J, Smith CIE, Vihinen M (2006) BTKbase: the mutation database for X-linked agammaglobulinemia. Hum Mutat 27(12):1209–1217. https://doi.org/10.1002/humu.20410
Article CAS PubMed Google Scholar
Tsukada S et al (1993) Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 72(2):279–290. https://doi.org/10.1016/0092-8674(93)90667-f
Article CAS PubMed Google Scholar
Riggs J, Howell K, Matechin B, Matlack R, Pennello A, Chiasson R (2003) X-chromosome-linked immune-deficient mice have B-1b cells. Immunology 108(4):440–451. https://doi.org/10.1046/j.1365-2567.2003.01624.x
Article CAS PubMed PubMed Central Google Scholar
Liu X et al (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12(5):416–424. https://doi.org/10.1038/ni.2015
Article CAS PubMed Google Scholar
Quek LS, Bolen J, Watson SP (1998) A role for Bruton’s tyrosine kinase (Btk) in platelet activation by collagen. Curr Biol 8(20):1137-S1. https://doi.org/10.1016/S0960-9822(98)70471-3
Article CAS PubMed Google Scholar
Honda F et al (2012) The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils. Nat Immunol 13(4):369–378. https://doi.org/10.1038/ni.2234
Article CAS PubMed Google Scholar
Genevier HC et al (1994) Expression of Bruton’s tyrosine kinase protein within the B cell lineage. Eur J Immunol 24(12):3100–3105. https://doi.org/10.1002/eji.1830241228
Article CAS PubMed Google Scholar
Katz FE et al (1994) Expression of the X-linked agammaglobulinemia gene, btk in B-cell acute lymphoblastic leukemia. Leukemia 8(4):574–577
Brullo C, Villa C, Tasso B, Russo E, Spallarossa A (2021) Btk inhibitors: a medicinal chemistry and drug delivery perspective. Int J Mol Sci 22(14):7641. https://doi.org/10.3390/ijms22147641
Article CAS PubMed PubMed Central Google Scholar
Manji F, Puckrin R, Stewart DA (2021) Novel synthetic drugs for the treatment of non-Hodgkin lymphoma. Expert Opin Pharmacother 22(11):1417–1427. https://doi.org/10.1080/14656566.2021.1902988
Article CAS PubMed Google Scholar
Schmidt U, Boucheron N, Unger B, Ellmeier W (2004) The role of Tec family kinases in myeloid cells. Int Arch Allergy Immunol 134(1):65–78. https://doi.org/10.1159/000078339
Article CAS PubMed Google Scholar
Hyvönen M, Saraste M (1997) Structure of the PH domain and Btk motif from Bruton’s tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia. EMBO J 16(12):3396–3404. https://doi.org/10.1093/emboj/16.12.3396
Article PubMed PubMed Central Google Scholar
Várnai P, Rother KI, Balla T (1999) Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton’s tyrosine kinase pleckstrin homology domain visualized in single living cells. J Biol Chem 274(16):10983–10989. https://doi.org/10.1074/jbc.274.16.10983
Kang SW et al (2001) PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization. EMBO J 20(20):5692–5702. https://doi.org/10.1093/emboj/20.20.5692
Article CAS PubMed PubMed Central Google Scholar
Vihinen M, Nilsson L, Smith CI (1994) Tec homology (TH) adjacent to the PH domain. FEBS Lett 350(2–3):263–265. https://doi.org/10.1016/0014-5793(94)00783-7
Article CAS PubMed Google Scholar
Park H et al (1996) Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity 4(5):515–525. https://doi.org/10.1016/s1074-7613(00)80417-3
Article CAS PubMed Google Scholar
Wahl MI, Fluckiger AC, Kato RM, Park H, Witte ON, Rawlings DJ (1997) Phosphorylation of two regulatory tyrosine residues in the activation of Bruton’s tyrosine kinase via alternative receptors. Proc Natl Acad Sci U S A 94(21):11526–11533. https://doi.org/10.1073/pnas.94.21.11526
Article CAS PubMed PubMed Central Google Scholar
Pan Z et al (2007) Discovery of selective irreversible inhibitors for Bruton’s tyrosine kinase. ChemMedChem 2(1):58–61. https://doi.org/10.1002/cmdc.200600221
Article CAS PubMed Google Scholar
Bender AT et al (2017) Ability of Bruton’s tyrosine kinase inhibitors to sequester Y551 and prevent phosphorylation determines potency for inhibition of Fc receptor but not B-cell receptor signaling. Mol Pharmacol 91(3):208–219. https://doi.org/10.1124/mol.116.107037
Article CAS PubMed Google Scholar
Mohamed AJ, Vargas L, Nore BF, Backesjo CM, Christensson B, Smith CI (2000) Nucleocytoplasmic shuttling of Bruton’s tyrosine kinase. J Biol Chem 275(51):40614–40619. https://doi.org/10.1074/jbc.M006952200
Article CAS PubMed Google Scholar
Li T, Rawlings DJ, Park H, Kato RM, Witte ON, Satterthwaite AB (1997) Constitutive membrane association potentiates activation of Bruton tyrosine kinase. Oncogene 15(12):1375–1383. https://doi.org/10.1038/sj.onc.1201308
Article CAS PubMed Google Scholar
Li Z, Wahl MI, Eguinoa A, Stephens LR, Hawkins PT, Witte ON (1997) Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases. Proc Natl Acad Sci U S A 94(25):13820–13825
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