Osgood CL, Maloney N, Kidd CG, Kitchen-Goosen S, Segars L, Gebregiorgis M, et al. Identification of mithramycin analogues with improved targeting of the EWS-FLI1 transcription factor. Clin Cancer Res. 2016;22(16):4105–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marchetto A, Ohmura S, Orth MF, Knott MML, Colombo MV, Arrigoni C, et al. Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma. Nat Commun. 2020;11(1):2423.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang R, Hu J, Zhou H, Wei H, He S, Xiao J. A novel defined hypoxia-related gene signature for prognostic prediction of patients with ewing sarcoma. Front Genet. 2022;13: 908113.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fleuren ED, Versleijen-Jonkers YM, van de Luijtgaarden AC, Molkenboer-Kuenen JD, Heskamp S, Roeffen MH, et al. Predicting IGF-1R therapy response in bone sarcomas: immuno-SPECT imaging with radiolabeled R1507. Clin Cancer Res. 2011;17(24):7693–703.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takahashi A, de Andrés MC, Hashimoto K, Itoi E, Oreffo RO. Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis. Osteoarthritis Cartil. 2015;23(11):1946–54.

Article  CAS  Google Scholar 

Feinberg AP, Irizarry RA, Fradin D, Aryee MJ, Murakami P, Aspelund T, et al. Personalized epigenomic signatures that are stable over time and covary with body mass index. Sci Transl Med. 2010;2(49):4967.

Article  Google Scholar 

Janssens Y, Wynendaele E, VandenBerghe W, De Spiegeleer B. Peptides as epigenetic modulators: therapeutic implications. Clin Epigenetics. 2019;11(1):101.

Article  PubMed  PubMed Central  Google Scholar 

Jung SE, Shin KJ, Lee HY. DNA methylation-based age prediction from various tissues and body fluids. BMB Rep. 2017;50(11):546–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong X, Kim ES, Guo H. Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B. Hepatology (Baltimore, MD). 2017;66(6):2066–77.

Article  CAS  PubMed  Google Scholar 

Yu X, Li Z. Epigenetic deregulations in chordoma. Cell Prolif. 2015;48(5):497–502.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stahl M, Kohrman N, Gore SD, Kim TK, Zeidan AM, Prebet T. Epigenetics in cancer: a hematological perspective. PLoS Genet. 2016;12(10): e1006193.

Article  PubMed  PubMed Central  Google Scholar 

Parrish JK, Sechler M, Winn RA, Jedlicka P. The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing Sarcoma. Oncogene. 2015;34(2):257–62.

Article  CAS  PubMed  Google Scholar 

Carrico C, Meyer JG, He W, Gibson BW, Verdin E. The mitochondrial acylome emerges: proteomics, regulation by sirtuins, and metabolic and disease implications. Cell Metab. 2018;27(3):497–512.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Valerio DG, Xu H, Eisold ME, Woolthuis CM, Pandita TK, Armstrong SA. Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice. Blood. 2017;129(1):48–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roccaro AM, Sacco A, Jia X, Azab AK, Maiso P, Ngo HT, et al. microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia. Blood. 2010;116(9):1506–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Otterson GA, Hodgson L, Pang H, Vokes EE. Phase II study of the histone deacetylase inhibitor Romidepsin in relapsed small cell lung cancer (Cancer and Leukemia Group B 30304). J Thorac Oncol. 2010;5(10):1644–8.

Article  PubMed  PubMed Central  Google Scholar 

García-Domínguez DJ, Hajji N, Sánchez-Molina S, Figuerola-Bou E, de Pablos RM, Espinosa-Oliva AM, et al. Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma. Oncogene. 2021;40(39):5843–53.

Article  PubMed  PubMed Central  Google Scholar 

Di Pompo G, Salerno M, Rotili D, Valente S, Zwergel C, Avnet S, et al. Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J Med Chem. 2015;58(9):4073–9.

Article  PubMed  Google Scholar 

Sampson VB, Vetter NS, Kamara DF, Collier AB, Gresh RC, Kolb EA. Vorinostat enhances cytotoxicity of SN-38 and temozolomide in ewing sarcoma cells and activates STAT3/AKT/MAPK pathways. PLoS ONE. 2015;10(11): e0142704.

Article  PubMed  PubMed Central  Google Scholar 

Sonnemann J, Dreyer L, Hartwig M, Palani CD, le Hong TT, Klier U, et al. Histone deacetylase inhibitors induce cell death and enhance the apoptosis-inducing activity of TRAIL in Ewing’s sarcoma cells. J Cancer Res Clin Oncol. 2007;133(11):847–58.

Article  CAS  PubMed  Google Scholar 

Jing Z, Ziwang F, Yinhang W, Yani Z, Jian C, Jingwen W, et al. Novel acetylation-related gene signatures for predicting the prognosis of patients with colorectal cancer. Hum Cell. 2022;35(4):1159–73.

Article  CAS  PubMed  Google Scholar 

Dai Q, Ye Y. Development and validation of a novel histone acetylation-related gene signature for predicting the prognosis of ovarian cancer. Front Cell Dev Biol. 2022;10: 793425.

Article  PubMed  PubMed Central  Google Scholar 

Falkenberg KJ, Johnstone RW. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Nat Rev Drug Discov. 2014;13(9):673–91.

Article  CAS  PubMed  Google Scholar 

Sajadian SO, Tripura C, Samani FS, Ruoss M, Dooley S, Baharvand H, et al. Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7. Clin Epigenetics. 2016;8:46.

Article  PubMed  PubMed Central  Google Scholar 

Lay FD, Liu Y, Kelly TK, Witt H, Farnham PJ, Jones PA, et al. The role of DNA methylation in directing the functional organization of the cancer epigenome. Genome Res. 2015;25(4):467–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hill RJ, Crossan GP. DNA cross-link repair safeguards genomic stability during premeiotic germ cell development. Nat Genet. 2019;51(8):1283–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nacev BA, Jones KB, Intlekofer AM, Yu JSE, Allis CD, Tap WD, et al. The epigenomics of sarcoma. Nat Rev Cancer. 2020;20(10):608–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farria A, Li W, Dent SY. KATs in cancer: functions and therapies. Oncogene. 2015;34(38):4901–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rezapour S, Hosseinzadeh E, Marofi F, Hassanzadeh A. Epigenetic-based therapy for colorectal cancer: prospect and involved mechanisms. J Cell Physiol. 2019;234(11):19366–83.

Article  CAS  PubMed