Comparative efficacy of topical 10% versus 5% tranexamic acid in treatment of women with melasma: a double-blind randomized controlled trial

Rodrigues M, Pandya AG. Hypermelanoses. In: Kang S, Amagai M, Bruckner AL, et al., editors. Fitzpatrick's dermatology 9th ed. New York: McGraw Hill; 2019. pp. 1361–40.

Panchal VS, Patel YS, Dalal YD, Parikh AP, Dalal AD, Rana DA. Efficacy of oral, topical, and intradermal tranexamic acid in patients with melasma – a meta-analysis. Indian Dermatol Online J 2024;15:55–63. doi: 10.4103/idoj.idoj_495_22.

Mawu F, Kapantow G. Melasma. In: Mawu F, Kapantow G, editors. Kelainan pigmentasi kulit. [Disorders of skin pigmentation]. Manado: Unsrat Press; 2020. pp. 77–87.

Majid I, Aleem S. Melasma: update on epidemiology, clinical presentation, assessment, and scoring. J Skin Stem Cell 2021;8:e120283. doi: 10.5812/jssc.120283.

Murlistayrini S, Nugrahani AF, Rahmawati YD, Wilanti NW. Studi retrospektif: profil melasma di rumah sakit dr. Saiful Anwar Malang periode 2015-2017. [Retrospective study: Melasma profile in dr. Saiful Anwar Hospital, Malang, for 2015-2017.] J Dermatol Venereol Aesthetic 2020;1:95-103. Indonesian.

Taraz M, Niknam S, Ehsani AH. Tranexamic acid in treatment of melasma: A comprehensive review of clinical studies. Dermatol Ther 2017;e12465. doi: 10.1111/dth.12465.

Atefi N, Dalvand B, Ghassemi M, Mehran G, Hedarian A. Therapeutic effects of topical tranexamic acid in comparison with hydroquinone in treatment of women with melasma. Dermatol Ther 2017;7:417-24. doi: 10.1007/s13555-017-0195-0.

Janney MS, Subramaniyan R, Dabas R, Lal S, Das NM, Godara SK. A randomized controlled study comparing the efficacy of topical 5% tranexamic acid solution versus 3% hydroquinone cream in melasma. J Cutan Aesthet Surg 2019;12:63-7. doi: 10.4103/JCAS.JCAS_40_18.

Nair A, Jacob S, Al-Dhubiab B, Attimarad M, Harsha S. Basic considerations in the dermatokinetics of topical formulations. Braz J Pharm Sci 2013;49:423-34. doi: 10.1590/S1984-82502013000300004.

Do LHD, Law RM, Maibach HI. Dose response effect of chemical surface concentration on percutaneous penetration in human: In vivo + in vitro. Regul Toxicol Pharmacol 2022;132:105186. doi: 10.1016/j.yrtph.2022.105186.

Saka S, Rao GRR, Komaram RB, Kotha S, Tatavarthi R, Chitturi LP. Efficacy of 10% topical tranexamic acid in melasma – a randomized placebo-controlled split face study. Int J Pharm Sci Res 2019;10:2583-86. doi: 10.13040/IJPSR.0975-8232.10(5).2583-86.

Pandya AG, Hynan LS, Bhore R, et al. Reliability assessment and validation of the melasma area and severity index (MASI) and a new modified MASI scoring method. J Am Acad Dermatol 2010;64:78-83. doi: 10.1016/j.jaad.2009.10.051.

Rapalli VK, Singhvi G. Dermato-pharmacokinetic: assessment tools for topically applied dosage forms. Expert Opin Drug Deliv 2021;18:423-6. doi: 10.1080/17425247.2021.1856071.

Zhao L, Chen J, Bai B, et al. Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing. Front Pharmacol 2024;14:1333986. doi: 10.3389/fphar.2023.1333986.

Liang R, Luo H, Pan W, et al. Comparative efficacy and safety of tranexamic acid for melasma by different administration methods: a systematic review and network meta-analysis. J Cosmet Dermatol 2024;23:1150-64. doi: 10.1111/jocd.16104.

Anwar AI, Wahab S, Widita W, Nurdin AR, Budhiani S, Seweng A. Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals. Dermatol Ther 2019;32:e13146. doi: 10.1111/dth.13146.

Arora R, Sharma R. Study on effectiveness and safety of combination of daily 10% tranexamic acid gel application and weekly iontophoresis versus daily 10% tranexamic acid gel alone in treatment of melasma. Galore Int J Health Sci Res 2019;4:99–106.

Maeda K. Mechanism of action of topical tranexamic acid in the treatment of melasma and sun-induced skin hyperpigmentation. Cosmetics 2022;9: 108. doi: 10.3390/cosmetics9050108.

Zhang L, Tan WQ, Fang QQ, et al. Tranexamic acid for adults with melasma: a systematic review and meta-analysis. Biomed Res Int 2018:1–13. doi: 10.1155/2018/1683414.

Forbat E, Al-Niaimi F, Ali FR. The emerging importance of tranexamic acid in dermatology. Clin Exp Dermatol 2020;45:445-9. doi: 10.1111/ced.14115.

Sarkar R, Narayan RV, Vinay K, et al. Prescribing practices of tranexamic acid for melasma: Delphi consensus from the Pigmentary Disorders Society. Indian J Dermatol Venereol Leprol 2023;90:41-5. doi: 10.25259/IJDVL_1157_2022.

Pratama L, Murlistyarini S. Tranexamic acid in dermatology: a review. Jurnal Klinik Riset Kesehatan 2022;1:172-8. doi: 10.11594/jk-risk.01.3.5.

Kim SJ, Park JY, Shibata T, Fujiwara R, Kang HY. Efficacy and possible mechanisms of topical tranexamic acid in melasma. Clin Exp Dermatol 2016;41:480-5. doi: 10.1111/ced.12835.

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