Background Inconsistencies with guidelines or standards regarding nurses’ practice of vasoactive agent infusion have been documented. Adequate knowledge and positive attitudes are critical for compliance. However, there are currently no validated tools specifically designed to measure the knowledge and attitudes related to vasoactive agent infusions among nurses.

Objective The aim of this study was to develop and test the validity and reliability of the Chinese mainland version of Knowledge, Attitude, and Practice of Vasoactive Agents Infusions Questionnaire among nurses.

Methods The initial questionnaire items were developed through a comprehensive literature review, expert consultation, and pilot study. From February to June 2024, cross-sectional data were collected using convenience sampling from 538 nurses across 9 hospitals in Sichuan Province, China. The reliability and validity of the scale were evaluated through internal consistency reliability, inter-rater reliability, exploratory factor analysis, and confirmatory factor analysis.

Results The final version of the questionnaire included 33 items across 3 dimensions, explaining 78.04% of the variance, with item loadings ranging from 0.56 to 0.89. The content validity index ranged from 0.91 to 1.00, and the scale-level content validity index was 0.98. The overall Cronbach’s α for the questionnaire was 0.96, with Cronbach’s α for each dimension ranging from 0.96 to 0.98. The test-retest reliability for the entire questionnaire was 0.90, and for each dimension, it ranged from 0.90 to 0.94 (p < 0.05). The confirmatory factor analysis demonstrated acceptable fit indices for the three-dimensional model: χ²/(df) = 1.135, p = 0.200, RMSEA = 0.024, CFI = 0.986, TLI = 0.985, GFI = 0.884, and NFI = 0.895.

Conclusion The Knowledge, Attitude, and Practice of Vasoactive Agents Infusions Questionnaire demonstrates good reliability and validity, making it a reliable measurement tool for assessing nurses’ attitudes and knowledge related to vasoactive agents’ infusions. This version will facilitate further research and advancements in this specific field of study.

The authors have declared no competing interest.

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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

Ethical approval was obtained from Southwest Medical University Hospital, China, with ethical approval codes KY2024065. The informed consent will be posted first on the “Wenjuanxing” web application. Only if they agree will the questionnaires be displayed for them to complete. If they do not agree, they will be directed to “exit” the platform and will receive a “thank you” message. All participants have the right to refuse or withdraw from the study at any time without penalty. All information gathered for this study stored on a password-protected computer in the form of electronic files and kept confidential from those who do not have the right to know.

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