Upregulation of Apoptosis Related Genes in Clinically Normal Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Effort to Maintain Tissue Homeostasis

Global Cancer Observatory [cited 2024 February 13]; https://gco.iarc.fr/en

Chow LQM (2020) Head and Neck Cancer. N Engl J Med 382(1):60–72. https://doi.org/10.1056/NEJMra1715715

Article  CAS  PubMed  Google Scholar 

Tan Y, Wang Z, Xu M et al (2023) Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci 15(1):44. https://doi.org/10.1038/s41368-023-00249-w

Article  PubMed  PubMed Central  Google Scholar 

Mello FW, Melo G, Pasetto JJ, Silva CAB, Warnakulasuriya S, Rivero ERC (2019) The synergistic effect of tobacco and alcohol consumption on oral squamous cell carcinoma: a systematic review and meta-analysis. Clin Oral Investig 23(7):2849–2859. https://doi.org/10.1007/s00784-019-02958-1

Article  PubMed  Google Scholar 

Lechner M, Liu J, Masterson L, Fenton TR (2022) HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management. Nat Rev Clin Oncol 19(5):306–327. https://doi.org/10.1038/s41571-022-00603-7

Article  PubMed  PubMed Central  Google Scholar 

Katirachi SK, Gronlund MP, Jakobsen KK, Gronhoj C, von Buchwald C (2023) The prevalence of HPV in oral cavity squamous cell carcinoma. Viruses 15(2). https://doi.org/10.3390/v15020451

Matsuo K, Akiba J, Kusukawa J, Yano H (2022) Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis. Am J Physiol Cell Physiol 323(6):C1611–C23. https://doi.org/10.1152/ajpcell.00098.2022

Article  CAS  PubMed  Google Scholar 

Shetty SS, Kudpaje A, Jayaraj R, Rao V, Shah PK (2019) Tongue cancer: a discrete oral cavity subsite. Oral Oncol 99:104348. https://doi.org/10.1016/j.oraloncology.2019.06.029

Article  PubMed  Google Scholar 

Pickering CR, Zhang J, Neskey DM et al (2014) Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers. Clin Cancer Res 20(14):3842–3848. https://doi.org/10.1158/1078-0432.CCR-14-0565

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vettore AL, Ramnarayanan K, Poore G et al (2015) Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance. Genome Med 7(1):98. https://doi.org/10.1186/s13073-015-0219-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu X, Coates PJ, Boldrup L et al (2019) Copy number variation: a prognostic marker for young patients with squamous cell carcinoma of the oral tongue. J Oral Pathol Med 48(1):24–30. https://doi.org/10.1111/jop.12792

Article  CAS  PubMed  Google Scholar 

Gu X, Wang L, Coates PJ et al (2023) Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue. J Pathol 259(1):93–102. https://doi.org/10.1002/path.6025

Article  PubMed  Google Scholar 

Arantes L, Cruvinel-Carloni A, de Carvalho AC et al (2020) TERT promoter mutation C228T increases risk for Tumor recurrence and death in Head and Neck Cancer patients. Front Oncol 10:1275. https://doi.org/10.3389/fonc.2020.01275

Article  PubMed  PubMed Central  Google Scholar 

Jakubek YA, Chang K, Sivakumar S et al (2020) Large-scale analysis of acquired chromosomal alterations in non-tumor samples from patients with cancer. Nat Biotechnol 38(1):90–96. https://doi.org/10.1038/s41587-019-0297-6

Article  CAS  PubMed  Google Scholar 

Wu P, Xie C, Yang L et al (2021) The genomic architectures of tumour-adjacent tissues, plasma and saliva reveal evolutionary underpinnings of relapse in head and neck squamous cell carcinoma. Br J Cancer 125(6):854–864. https://doi.org/10.1038/s41416-021-01464-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Slaughter DP, Southwick HW, Smejkal W (1953) Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6(5):963–968

Article  CAS  PubMed  Google Scholar 

Curtius K, Wright NA, Graham TA (2018) An evolutionary perspective on field cancerization. Nat Rev Cancer 18(1):19–32. https://doi.org/10.1038/nrc.2017.102

Article  CAS  PubMed  Google Scholar 

Lochhead P, Chan AT, Nishihara R et al (2015) Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression. Mod Pathol 28(1):14–29. https://doi.org/10.1038/modpathol.2014.81

Article  PubMed  Google Scholar 

Aran D, Camarda R, Odegaard J et al (2017) Comprehensive analysis of normal adjacent to tumor transcriptomes. Nat Commun 8(1):1077. https://doi.org/10.1038/s41467-017-01027-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boldrup L, Gu X, Coates PJ et al (2017) Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma. Oncotarget 8(12):19389–19402. https://doi.org/10.18632/oncotarget.14288

Article  PubMed  Google Scholar 

Sanz-Pamplona R, Berenguer A, Cordero D et al (2014) Aberrant gene expression in mucosa adjacent to tumor reveals a molecular crosstalk in colon cancer. Mol Cancer 13:46. https://doi.org/10.1186/1476-4598-13-46

Article  CAS  PubMed  PubMed Central  Google Scholar 

Risk MC, Knudsen BS, Coleman I et al (2010) Differential gene expression in benign prostate epithelium of men with and without prostate cancer: evidence for a prostate cancer field effect. Clin Cancer Res 16(22):5414–5423. https://doi.org/10.1158/1078-0432.CCR-10-0272

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang X, Stern DF, Zhao H (2016) Transcriptional profiles from paired normal samples offer complementary information on Cancer patient survival–evidence from TCGA Pan-cancer Data. Sci Rep 6:20567. https://doi.org/10.1038/srep20567

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oh E, Lee H (2023) Transcriptomic data in tumor-adjacent normal tissues harbor prognostic information on multiple cancer types. Cancer Med 12(10):11960–11970. https://doi.org/10.1002/cam4.5864

Article  PubMed  PubMed Central  Google Scholar 

Attaran N, Gu X, Coates PJ et al (2020) Downregulation of TAP1 in Tumor-Free Tongue Contralateral to squamous cell carcinoma of the oral Tongue, an Indicator of Better Survival. Int J Mol Sci 21(17). https://doi.org/10.3390/ijms21176220

Gu X, Boldrup L, Coates PJ et al (2019) High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue. J Pathol Clin Res 5(4):240–247. https://doi.org/10.1002/cjp2.138

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi W, Oshlack A, Smyth GK (2010) Optimizing the noise versus bias trade-off for Illumina whole genome expression BeadChips. Nucleic Acids Res 38(22):e204. https://doi.org/10.1093/nar/gkq871

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van der Auwera GA (2020) OCB, Genomics in the Cloud: Using Docker, GATK, and WDL in Terra (1st Edition). : O’Reilly Media

McKenna A, Hanna M, Banks E et al (2010) The genome analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res 20(9):1297–1303. https://doi.org/10.1101/gr.107524.110

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim D, Langmead B, Salzberg SL (2015) HISAT: a fast spliced aligner with low memory requirements. Nat Methods 12(4):357–360. https://doi.org/10.1038/nmeth.3317

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pertea M, Pertea GM, Antonescu CM, Chang TC, Mendell JT, Salzberg SL (2015) StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nat Biotechnol 33(3):290–295.

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