Richardson MS, Muller S (2014) Malignant odontogenic tumors: an update on selected tumors. Head Neck Pathol 8(4):411–420. https://doi.org/10.1007/s12105-014-0584-y

Article  PubMed  PubMed Central  Google Scholar 

Guimaraes LM, Coura BP, Gomez RS, Gomes CC (2021) The molecular pathology of odontogenic tumors: expanding the spectrum of MAPK pathway driven tumors. Front Oral Health 2:740788. https://doi.org/10.3389/froh.2021.740788

Article  PubMed  PubMed Central  Google Scholar 

Odell EW. Chapter 7: Odontogenic and Maxillofacial Bone Tumours. In: World Health Organization Classification of Tumours Editorial Board Head and neck tumours. 5th ed. Lyon (France): International Agency for Research on Cancer; Forthcoming.

Soluk-Tekkesin M, Wright JM (2022) The world health organization classification of odontogenic lesions: a summary of the changes of the 2022 (5th) edition. Turk Patoloji Derg 38(2):168–184. https://doi.org/10.5146/tjpath.2022.01573

Article  PubMed  PubMed Central  Google Scholar 

Niu Z, Li Y, Chen W, Zhao J, Zheng H, Deng Q et al (2020) Study on clinical and biological characteristics of ameloblastic carcinoma. Orphanet J Rare Dis 15(1):316. https://doi.org/10.1186/s13023-020-01603-5

Article  PubMed  PubMed Central  Google Scholar 

Vered M, Wright JM (2022) Update from the 5th edition of the world health organization classification of head and neck tumors: odontogenic and maxillofacial bone tumours. Head Neck Pathol 16(1):63–75. https://doi.org/10.1007/s12105-021-01404-7

Article  PubMed  PubMed Central  Google Scholar 

Lei Y (2014) Recent advances in the ancillary studies for diagnosing odontogenic carcinomas. J Adv Oral Res 5(1):1–2. https://doi.org/10.1177/2229411220140101

Article  Google Scholar 

Villegas KM, Paparella ML (2022) Malignant odontogenic tumors. A report of a series of 30 cases and review of the literature. Oral Oncol 134:106068. https://doi.org/10.1016/j.oraloncology.2022.106068

Article  PubMed  Google Scholar 

Meer S, Galpin JS, Atini M, Coleman H, Ali H (2003) Proliferating cell nuclear antigen and Ki67 immunoreactivity in ameloblastomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95(2):213–221. https://doi.org/10.1067/moe.2003.62

Article  PubMed  Google Scholar 

Scholzen T, Gerdes J (2000) The Ki-67 protein: from the known and the unknown. J Cell Physiol 182(3):311–322. https://doi.org/10.1002/(Sici)1097-4652(200003)182:3%3c311::Aid-Jcp1%3e3.0.Co;2-9

Article  CAS  PubMed  Google Scholar 

Phattarataratip E, Panitkul T, Khodkaew W, Anupuntanun P, Jaroonvechatam J, Pitarangsikul S (2021) Expression of SOX2 and OCT4 in odontogenic cysts and tumors. Head Face Med 17(1):29. https://doi.org/10.1186/s13005-021-00283-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tseng CH, Lu PH, Wang YP, Chang JYF (2022) Enrichment of SOX2-positive cells in BRAF V600E mutated and recurrent ameloblastoma. J Pers Med. https://doi.org/10.3390/jpm12010077

Article  PubMed  PubMed Central  Google Scholar 

Mendes RB, Dias RB, Figueiredo AL, Gurgel CA, Santana Filho M, Melo LA et al (2017) Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study. J Oral Pathol Med 46(4):297–300. https://doi.org/10.1111/jop.12501

Article  CAS  PubMed  Google Scholar 

Lei Y, Jaradat JM, Owosho A, Adebiyi KE, Lybrand KS, Neville BW et al (2014) Evaluation of SOX2 as a potential marker for ameloblastic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol 117(5):608-U3363. https://doi.org/10.1016/j.oooo.2014.01.017

Article  PubMed  Google Scholar 

Hagey DW, Klum S, Kurtsdotter I, Zaouter C, Topcic D, Andersson O et al (2018) SOX2 regulates common and specific stem cell features in the CNS and endoderm derived organs. PLoS Genet 14(2):e1007224. https://doi.org/10.1371/journal.pgen.1007224

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sarkar A, Hochedlinger K (2013) The sox family of transcription factors: versatile regulators of stem and progenitor cell fate. Cell Stem Cell 12(1):15–30. https://doi.org/10.1016/j.stem.2012.12.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weina K, Utikal J (2014) SOX2 and cancer: current research and its implications in the clinic. Clin Transl Med 3:19. https://doi.org/10.1186/2001-1326-3-19

Article  PubMed  PubMed Central  Google Scholar 

Zhang S, Xiong X, Sun Y (2020) Functional characterization of SOX2 as an anticancer target. Signal Transduct Target Ther 5(1):135. https://doi.org/10.1038/s41392-020-00242-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gurgel CAS, Buim MEC, Carvalho KC, Sales CBS, Reis MG, de Souza RO et al (2014) Transcriptional profiles of SHH pathway genes in keratocystic odontogenic tumor and ameloblastoma. J Oral Pathol Med 43(8):619–626. https://doi.org/10.1111/jop.12180

Article  CAS  PubMed  Google Scholar 

Ge N, Lin HX, Xiao XS, Guo L, Xu HM, Wang X et al (2010) Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma. J Transl Med. https://doi.org/10.1186/1479-5876-8-94

Article  PubMed  PubMed Central  Google Scholar 

Lou XY, Han X, Jin CM, Tian W, Yu W, Ding D et al (2013) SOX2 targets fibronectin 1 to promote cell migration and invasion in ovarian cancer: new molecular leads for therapeutic intervention. OMICS 17(10):510–518. https://doi.org/10.1089/omi.2013.0058

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kitamura H, Torigoe T, Hirohashi Y, Asanuma H, Inoue R, Nishida S et al (2013) Prognostic impact of the expression of ALDH1 and SOX2 in urothelial cancer of the upper urinary tract. Mod Pathol 26(1):117–124. https://doi.org/10.1038/modpathol.2012.139

Article  CAS  PubMed  Google Scholar 

Rodriguez-Pinilla SM, Sarrio D, Moreno-Bueno G, Rodriguez-Gil Y, Martinez MA, Hernandez L et al (2007) Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer. Mod Pathol 20(4):474–481. https://doi.org/10.1038/modpathol.3800760

Article  CAS  PubMed  Google Scholar 

Wang X, Liang Y, Chen Q, Xu HM, Ge N, Luo RZ et al (2012) Prognostic significance of SOX2 expression in nasopharyngeal carcinoma. Cancer Invest 30(1):79–85. https://doi.org/10.3109/07357907.2011.630049

Article  CAS  PubMed  Google Scholar 

Wang Q, He W, Lu CD, Wang Z, Wang JS, Giercksky KE et al (2009) Oct3/4 and Sox2 Are significantly associated with an unfavorable clinical outcome in human esophageal squamous cell carcinoma. Anticancer Res 29(4):1233–1241

CAS  PubMed  Google Scholar 

Du LT, Yang YM, Xiao XY, Wang CX, Zhang XH, Wang LL et al (2011) Sox2 nuclear expression is closely associated with poor prognosis in patients with histologically node-negative oral tongue squamous cell carcinoma. Oral Oncol 47(8):709–713. https://doi.org/10.1016/j.oraloncology.2011.05.017

Article  CAS  PubMed  Google Scholar 

Li ASM, Siu MKY, Zhang HJ, Wong ESY, Chan KYK, Ngan HYS et al (2008) Hypermethylation of SOX2 gene in hydatidiform mole and choriocarcinoma. Reprod Sci 15(7):735–744. https://doi.org/10.1177/1933719108322433

Article  CAS  PubMed  Google Scholar 

Maehara R, Fujikura K, Takeuchi K, Akita M, Abe-Suzuki S, Karbanova J et al (2018) SOX2-silenced squamous cell carcinoma: a highly malignant form of esophageal cancer with SOX2 promoter hypermethylation. Mod Pathol 31(1):83–92. https://doi.org/10.1038/modpathol.2017.112

Article  CAS  PubMed  Google Scholar 

Otsubo T, Akiyama Y, Yanagihara K, Yuasa Y (2008) SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. Br J Cancer 98(4):824–831. https://doi.org/10.1038/sj.bjc.6604193