Pitfalls in Diagnosis of Myoepithelial Carcinoma of Salivary Glands: A Study of 3 Cases with Cytologic-histologic Correlation and Molecular Analysis

Cormier C, Agarwal S (2022) Myoepithelial Carcinoma Ex-pleomorphic Adenoma: a Rare Pathology misdiagnosed as Pleomorphic Adenoma; with a novel TERT promoter mutation and high PD-L1 expression. Head Neck Pathol 16(1):322–330

Article  PubMed  Google Scholar 

Xu B, Mneimneh W, Torrence DE et al (2019) Misinterpreted myoepithelial carcinoma of salivary gland: a challenging and potentially signifcant pitfall. Am J Surg Pathol 43(5):601–609. https://doi.org/10.1097/PAS.0000000000001218

Article  PubMed  PubMed Central  Google Scholar 

Brenda L, Nelson, Thompson LDR (2022) Myoepithelial carcinoma. In: Diagnostic Pathology, Head and neck, 3rd Edition. Philadeplphia: Elsevier; pp. 636–639

Said S, Campana J (2005) Myoepithelial carcinoma ex pleomorphic adenoma of salivary glands: a problematic diagnosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:196–201

Article  PubMed  Google Scholar 

Brandwein-Gensler M, Bell D, Inagaki H, Katabi N, Leivo I, Seethala R, Triantafyllou A (2005) Malignant tumours of the salivary gland. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (eds) World Health Organization classification of Head and Neck tumors. IARC, Lyon, pp 160–184

Google Scholar 

Kong M, Drill EN, Morris L et al (2015) Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. Am J Surg Pathol 39(7):931–938

Article  PubMed  PubMed Central  Google Scholar 

Argyris PP, Wakely PE Jr (2023 Nov-Dec) Cytopathology of salivary gland myoepithelial carcinoma: a study of 13 cases and review of the literature. J Am Soc Cytopathol 12(6):461–468

Darvishian F, Lin O (2004) Myoepithelial cell-rich neoplasms: cytologic features of benign and malignant lesions. Cancer 102(6):355–361

Article  PubMed  Google Scholar 

Guo X, Watanabe J, Ariyasu S, Sasaguri Y, Kurose N, Fukushima K, Yamada S (2018) Myoepithelial carcinoma of the parotid gland: a case of adequate fine-needle aspiration cytology specimens rendering a conclusive diagnosis possible. SAGE Open Med Case Rep 6:2050313X18780842

Article  PubMed  PubMed Central  Google Scholar 

DiPalma S, Alasio L, Pilotti S (1996) Fine needle aspiration (FNA) appearances of malignant myoepithelioma of the parotid gland. Cytopathology 7:357–365

Article  PubMed  CAS  Google Scholar 

Chhieng DC, Paulino AF (2002) Cytology of myoepithelial carcinoma of the salivary gland. Cancer 96:32–36

Article  PubMed  Google Scholar 

Sehgal S, Goyal P, Singh S, Kumar A (2013) Fine-needle aspiration cytology of myoepithelial carcinoma of salivary gland: diagnostic challenge to cytopathologist. J Cytol 30(3):207–210

Article  PubMed  PubMed Central  Google Scholar 

Xu B, Katabi N (2021) Myoepithelial Carcinoma. Surg Pathol Clin 14(1):67–73. https://doi.org/10.1016/j.path.2020.09.008Epub 2021 Jan 5

Article  PubMed  PubMed Central  Google Scholar 

Savera AT, Sloman A, Huvos AG, Klimstra DS (2000) Myoepithelial carcinoma of the salivary glands: a clinicopathologic study of 25 patients. Am J Surg Pathol 24(6):761–774. https://doi.org/10.1097/00000478-200006000-00001

Article  PubMed  CAS  Google Scholar 

Dalin MG, Katabi N, Persson M et al (2017) Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. Nat Commun 8:1197

Article  PubMed  PubMed Central  Google Scholar 

Skálová A, Weinreb I, Hyrcza M, Simpson RH, Laco J, Agaimy A, Vazmitel M, Majewska H, Vanecek T, Talarčik P, Manajlovic S, Losito SN, Šteiner P, Klimkova A, Michal M (2015) Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component. Am J Surg Pathol 39(3):338–348

Article  PubMed  Google Scholar 

Bahrami A, Dalton JD, Shivakumar B et al (2012) PLAG1 alteration in carcinoma ex pleomorphic adenoma: immunohistochemical and fluorescence in situ hybridization studies of 22 cases. Head Neck Pathol 6:328–335. https://doi.org/10.1007/s12105-012-0353-8

Article  PubMed  PubMed Central  Google Scholar 

Chiba K, Johnson JZ, Vogan JV, Wagner T, Boyle JM, Hockemeyer D (2015) Cancer-associated TERT promoter mutations abrogate telomerase silencing. Elife 4:e07918

Article  PubMed  PubMed Central  Google Scholar 

Shigeishi H, Sugiyama M, Tahara H, Ono S, Kumar Bhawal U, Okura M, Kogo M, Shinohara M, Shindoh M, Shintani S, Hamakawa H, Takata T, Kamata N (2011) Increased telomerase activity and hTERT expression in human salivary gland carcinomas. Oncol Lett 2(5):845–850

PubMed  PubMed Central  CAS  Google Scholar 

Owosho AA, Adesina OM, Odujoko O, Akinyemi H, Komolafe A, Tadros S, Bauer R, Summersgill KF (2022) HMGA2 immunoexpression is frequent in salivary gland pleomorphic adenoma: immunohistochemical and molecular analyses of PLAG1 and HMGA2 in 25 cases. Int J Clin Exp Pathol 15(2):63–71

PubMed  PubMed Central  CAS  Google Scholar 

Asahina M, Saito T, Hayashi T, Fukumura Y, Mi tani K, Yao T (2019) Clinicopathological effect of PLAG1 fusion genes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma with special emphasis on histological features. Histopathology 74:514–525

Article  PubMed  Google Scholar 

Mukaigawa T, Hayashi R, Hashimoto K et al (2016) Programmed death ligand-1 expression is associated with poor disease-free survival in salivary gland carcinomas. J Surg Oncol 114:36–43

Article  PubMed  CAS  Google Scholar 

Elsheikh TM, Bernacki EG (1996) Fine needle aspiration cytology of cellular pleomorphic adenoma. Acta Cytol 40:1165e1175

Article  Google Scholar 

Bijan Khademi T, Kazemi A, Bayat H, Bahranifard Y, Daneshbod (2010) Mohammad Mohammadianpanah; salivary gland Myoepithelial neoplasms: a clinical and cytopathologic study of 15 cases and review of the literature. Acta Cytol 1 Dec 54(6):1111–111726

Google Scholar 

Baloch Z, Fadda G, Griffith CG et al (2023) Neoplasms. In: WC Faquin, ED Rossi, Z Baloch, eds. The Milan System for Reporting Salivary Gland Cytopathology. Springer; 2nd edition

Comments (0)

No login
gif