Abd El-Rahman GI, Behairy A, Elseddawy NM, Batiha GES, Hozzein WN, Khodeer DM, Abdelhakim MY (2020a) Saussurea lappa ethanolic extract attenuates triamcinolone acetonide-induced pulmonary and splenic tissue damage in rats via modulation of oxidative stress, inflammation, and apoptosis. Antioxidants 9:396. https://doi.org/10.3390/antiox9050396

Article  CAS  PubMed Central  Google Scholar 

Abd El-Rahman M, Rezk MM, Ahmed-Farid OA, Essam S, Abdel Moneim AE (2020b) Saussurea lappa root extract ameliorates the hazards effect of thorium induced oxidative stress and neuroendocrine alterations in adult male rats. Environ Sci Pollut Res 27:13237–13246. https://doi.org/10.1007/s11356-020-07917-y

Article  CAS  Google Scholar 

Abdel-Moein KA, Saeed H, Samir A (2015) Novel detection of Helicobacter pylori in fish: a possible public health concern. Acta Trop 152:141–144. https://doi.org/10.1016/j.actatropica.2015.09.005

Article  PubMed  Google Scholar 

Adel M, Pourgholam R, Zorriehzahra J, Ghiasi M (2016) Hemato-Immunological and biochemical parameters, skin antibacterial activity, and survival in rainbow trout (Oncorhynchus mykiss) following the diet supplemented with Mentha piperita against Yersinia ruckeri. Fish Shellfish Immunol 55:267–273. https://doi.org/10.1016/j.fsi.2016.05.040

Article  CAS  PubMed  Google Scholar 

Ahn O, Petrell RJ, Harrison PJ (1998) Ammonium and nitrate uptake by Laminaria saccharina and Nereocystis luetkeana originating from a salmon sea cage farm. J Appl Phycol 10:333–340. https://doi.org/10.1023/A:1008092521651

Article  CAS  Google Scholar 

Akhtar MS, Riffat S (1991) Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children. J Pak Med Assoc 41(8):185–187

CAS  PubMed  Google Scholar 

Alnahdi HS, Ayaz NO, Elhalwagy ME (2016) Prophylactic effect of cousts Saussurea lappa against liver injury induced by deltamethrin intoxication. Int J Clin Exp Pathol 9(1):387–394

Google Scholar 

Amara U, Khan A, Laraib S, Wali R, Sarwar U, Ain QT, Shakeel S (2017) Conservation status and therapeutic potential of Saussurea lappa: An overview. Ame J Plant Sci 8(3):602–614

Article  CAS  Google Scholar 

Ansari S (2019) Ethnobotany and pharmacognosy of qust/kut (Saussurea lappa, CB Clarke) with special reference of Unani medicine. Pharmacogn Rev 13(26):71–76

Article  CAS  Google Scholar 

Ardó L, Yin G, Xu P, Váradi L, Szigeti G, Jeney Z, Jeney G (2008) Chinese herbs (Astragalus membranaceus and Lonicera japonica) and boron enhance the non-specific immune response of Nile tilapia (Oreochromis niloticus) and resistance against Aeromonas hydrophila. Aquaculture 275:26–33. https://doi.org/10.1016/j.aquaculture.2007.12.022

Article  CAS  Google Scholar 

Arias CA, Murray BE (2012) The rise of the Enterococcus: beyond vancomycin resistance. Nat Rev Microbiol 10:266–278. https://doi.org/10.1038/nrmicro2761

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bachelier A, Mayer R, Klein CD (2006) Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett 16:5605–5609. https://doi.org/10.1016/j.bmcl.2006.08.021

Article  CAS  PubMed  Google Scholar 

Bains S, Thakur V, Kaur J, Singh K, Kaur R (2019) Elucidating genes involved in sesquiterpenoid and flavonoid biosynthetic pathways in Saussurea lappa by de novo leaf transcriptome analysis. Genomics 111:1474–1482. https://doi.org/10.1016/j.ygeno.2018.09.022

Article  CAS  PubMed  Google Scholar 

Begam M, Sengupta M (2015) Immunomodulation of intestinal macrophages by mercury involves oxidative damage and rise of pro-inflammatory cytokine release in the fresh water fish Channa punctatus Bloch. Fish Shellfish Immunol 45:378–385. https://doi.org/10.1016/j.fsi.2015.04.017

Benedetto C, D’Auria M, Mecca M, Prasad P, Singh P, Singh S, Sinisgalli C, Milella L (2019) Chemical and biological evaluation of essential oil from Saussurea costus (Falc.) lipsch. from Garhwal Himalaya collected at different harvesting periods. Nat Prod Res 33:2355–2358. https://doi.org/10.1080/14786419.2018.1440219

Boshra H, Li J, Sunyer JO (2006) Recent advances on the complement system of teleost fish. Fish Shellfish Immunol 20:239–262. https://doi.org/10.1016/j.fsi.2005.04.004

Article  CAS  PubMed  Google Scholar 

Brown EJ (1992) Complement receptors, adhesion, and phagocytosis. Infect Agents Dis 1:63–70

CAS  PubMed  Google Scholar 

Caamano J, Hunter CA (2002) NF-κB family of transcription factors: central regulators of innate and adaptive immune functions. Clin Microbiol Rev 15:414–429. https://doi.org/10.1128/cmr.15.3.414-429.2002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chai JY, Murrell KD, Lymbery AJ (2005) Fish-borne parasitic zoonoses: status and issues. Int J Parasitol 35:1233–1254. https://doi.org/10.1016/j.ijpara.2005.07.013

Article  PubMed  Google Scholar 

Chakraborty SB, Hancz C (2011) Application of phytochemicals as immunostimulant, antipathogenic and antistress agents in finfish culture. Rev Aquacult 3:103–119. https://doi.org/10.1111/j.1753-5131.2011.01048.x

Article  Google Scholar 

Chang KM, Choi SI, Kim GH (2012) Anti-oxidant activity of Saussurea lappa CB Clarke roots. Prev Nutr Food Sci 17:306. https://doi.org/10.3746/pnf.2012.17.4.306

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen D, Chen J, Huang J, Chen X, Feng D, Liang B, Che Y, Liu X, Zhu C, Li X, Shen H (2010) Epidemiological investigation of Clonorchis sinensis infection in freshwater fishes in the Pearl River Delta. Parasitol Res 107:835–839. https://doi.org/10.1007/s00436-010-1936-5

Article  PubMed  Google Scholar 

Chhabra BR, Ahuja NM, Bhullar MK, Kalsi PS (1998a) Some C-3 oxygenated guaianolides from Saussurea lappa. Fitoterapia 69:274–275

CAS  Google Scholar 

Chhabra BR, Gupta S, Jain M, Kalsi PS (1998b) Sesquiterpene lactones from Saussurea lappa. Phytochemistry 49:801–804. https://doi.org/10.1016/S0031-9422(97)00906-0

Article  CAS  Google Scholar 

Cho JY, Park J, Yoo ES, Baik KU, Jung JH, Lee J, Park MH (1998) Inhibitory effect of sesquiterpene lactones from Saussurea lappa on tumor necrosis factor-α production in murine macrophage-like cells. Planta Med 64:594–597. https://doi.org/10.1055/s-2006-957528

Article  CAS  PubMed  Google Scholar 

Cho JY, Baik KU, Jung JH, Park MH (2000) In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur J Pharmacol 398:399–407. https://doi.org/10.1016/S0014-2999(00)00337-X

Article  CAS  PubMed  Google Scholar 

Cho JY, Kim AR, Joo HG, Kim BH, Rhee MH, Yoo ES, Katz DR, Chain BM, Jung JH (2004a) Cynaropicrin, a sesquiterpene lactone, as a new strong regulator of CD29 and CD98 functions. Biochem Biophys Res Commun 313:954–961. https://doi.org/10.1016/j.bbrc.2003.12.026

Article  CAS  PubMed  Google Scholar 

Cho JY, Kim AR, Jung JH, Chun T, Rhee MH, Yoo ES (2004b) Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines. Eur J Pharmacol 492:85–94. https://doi.org/10.1016/j.ejphar.2004.03.027

Article  CAS  PubMed  Google Scholar 

Choi JH, Lee KT (2009) Costunolide-induced apoptosis in human leukemia cells: involvement of c-jun N-terminal kinase activation. Biol Pharm Bull 32:1803–1808. https://doi.org/10.1248/bpb.32.1803

Article  CAS  PubMed  Google Scholar 

Choi JY, Choi EH, Jung HW, Oh JS, Lee WH, Lee JG, Son JK, Kim Y, Lee SH (2008) Melanogenesis inhibitory compounds from Saussureae Radix. Arch Pharm Res 31:294–299. https://doi.org/10.1007/s12272-001-1154-0

Article  CAS  PubMed  Google Scholar 

Choi EM, Kim GH, Lee YS (2009) Protective effects of dehydrocostus lactone against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells. Toxicol in Vitro 23:862–867. https://doi.org/10.1016/j.tiv.2009.05.005

Article  CAS  PubMed  Google Scholar 

Choi HG, Lee DS, Li B, Choi YH, Lee SH, Kim YC (2012) Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells. Int Immunopharmacol 13:271–279. https://doi.org/10.1016/j.intimp.2012.04.016