Yuh-Fung Chen, Department of Pharmacology, China Medical University, Taichung 404328, TaiwanFollow
Kuo-Jen Wu, Department of Pharmacology, China Medical University, Taichung 404328, Taiwan
Chi-Chung Kuo, Department of Neurology, Taichung Tzu Chi Hospital, Taichung 427003, Taiwan
Huei-Yann Tsai, Department of Pharmacy, China Medical University Hospital, Taichung 404327, Taiwan

Background: Stroke is the leading cause of mortality and morbidity worldwide, and an effective therapeutic strategy for the prevention of patients with cerebral ischemiainduced brain injury is lacking. Traditional Chinese medicine with neuroprotective activities might be beneficial and provide alternative therapeutic opportunities for cerebral ischemia.Purposes: This study aimed to evaluate the neuroprotection and possible mechanisms of Gueichih-Fuling-Wan (GFW), its’ constitutive herbs, and their active compounds on cerebral ischemia/reperfusion (I/R)-induced brain injury in rodents.Methods: Various doses of extracts (0.25, 0.5, and 1.0 g/kg) of GFW and five constituent herbs (Cinnamomi Cortex, CC; Poria cocos, PC; Paeonia lactifloa, PL; Paeonia suffruticosa, PS and Prunus perisica, PP) were orally administered. Different doses of active compounds (0.5, 1.0, and 2.0 mg/kg) of GFW such as cinnamaldehyde, cinnamic acid (from CC), paeoniflorin (from PL), and paeonol (from PS) were intraperitoneally administered. Their effects on cerebral ischemia/reperfusion (I/R)-induced brain injury in rodents were evaluated.Results: GFW, its’ constituent herbs, and the active compounds reduced the infarct area dose-dependently (***P

Chen, Yuh-Fung; Wu, Kuo-Jen; Kuo, Chi-Chung; and Tsai, Huei-Yann (2024) "Protection of Gueichih-Fuling-Wan on cerebral ischemia-induced brain injury in rodents is mediated by trans-cinnamaldehyde via inhibition of neuroinflammation and apoptosis," BioMedicine: Vol. 14 : Iss. 2 , Article 4.
DOI: 10.37796/2211-8039.1449

DOWNLOADS

Since May 30, 2024