Shanza Azeez, Department of Biochemistry, Bahauddin Zakariya University, Multan, Pakistan
Mishal Fatima, Department of Biochemistry, Bahauddin Zakariya University, Multan, Pakistan
Ouz Gul, Department of Biochemistry, Bahauddin Zakariya University, Multan, Pakistan
Huzaifa Rehman, Department of Biochemistry, Bahauddin Zakariya University, Multan, Pakistan
Muhammad Aslam Shad, Department of Medical Sciences, Times Institute Multan, Multan, Pakistan
Haq Nawaz, Department of Biochemistry, Bahauddin Zakariya University, Multan, PakistanFollow

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and synovial joint destruction.

Aims: The current study investigated the possible beneficial effect of zinc oxide nanoparticles-doped curcumin (ZnONPs-DC) on the recovery of RA and antioxidant status of experimental rabbits.

Methods: RA was induced in experimental rabbits by injecting complete Freund's adjuvant and collagen type-II emulsion (100 µL/kg body weight) in the base of their tail. Arthritic rabbits were orally treated with ZnONPs, curcumin, and ZnONPs-DC (250 µL/kg body weight). Serum samples from the control and study groups were collected before and after RA induction and after treatment. The sera were subjected to analysis of biological markers of RA and antioxidant status.

Results: The complete Freund's adjuvant and collagen type II treatment resulted in positive rheumatoid factor and C-reactive protein elevated oxidative stress and decreased antioxidant potential. Each treatment showed the absence of rheumatoid factor and C-reactive protein decreased oxidative stress and improved antioxidant potential compared to the control. However, ZnONPs-DC treatment showed a comparatively higher decline in serum malondialdehyde MDA content and an elevation in the antioxidant activity of RA animals.

Conclusions: In conclusion, using zinc oxide nanoparticles-doped curcumin may be an effective anti-arthritic and anti-inflammatory drug in controlling RA.

Azeez, Shanza; Fatima, Mishal; Gul, Ouz; Rehman, Huzaifa; Shad, Muhammad Aslam; and Nawaz, Haq (2024) "Zinc Oxide Nanoparticles-Doped Curcumin-Assisted Recovery of Rheumatoid Arthritis and Antioxidant Status in Experimental Rabbits," BioMedicine: Vol. 14 : Iss. 2 , Article 5.
DOI: 10.37796/2211-8039.1446

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