Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration

Collaborators GBDLRoS, Feigin VL, Nguyen G, Cercy K, Johnson CO, Alam T, et al. Global, regional, and country-specific lifetime risks of stroke, 1990 and 2016. N Engl J Med. 2018;379:2429–37.

Article  Google Scholar 

Seners P, Turc G, Naggara O, Henon H, Piotin M, Arquizan C, et al. Post-thrombolysis recanalization in stroke referrals for thrombectomy: incidence, predictors, and prediction scores. Stroke. 2018;49:2975–82.

Article  PubMed  Google Scholar 

Patel P, Yavagal D, Khandelwal P. Hyperacute management of ischemic strokes: JACC focus seminar. J Am Coll Cardiol. 2020;75:1844–56.

Article  PubMed  Google Scholar 

Beuker C, Strecker J-K, Rawal R, Schmidt-Pogoda A, Ruck T, Wiendl H, et al. Immune cell infiltration into the brain after ischemic stroke in humans compared to mice and rats: a systematic review and meta-analysis. Transl Stroke Res. 2021;12:976–90.

Article  PubMed  PubMed Central  Google Scholar 

Gullotta GS, De Feo D, Friebel E, Semerano A, Scotti GM, Bergamaschi A, et al. Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology. Nat Immunol. 2023;24:925–40.

Article  CAS  PubMed  Google Scholar 

Gong P, Liu Y, Gong Y, Chen G, Zhang X, Wang S, et al. The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke. J Neuroinflammation. 2021;18:51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jickling GC, Liu D, Ander BP, Stamova B, Zhan X, Sharp FR. Targeting neutrophils in ischemic stroke: translational insights from experimental studies. J Cereb Blood Flow Metab. 2015;35:888–901.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jayaraj RL, Azimullah S, Beiram R, Jalal FY, Rosenberg GA. Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflammation. 2019;16:142.

Article  PubMed  PubMed Central  Google Scholar 

Quan X, Liang X, Ding Y, Han Y, Li J, Yuan M, et al. Cryo-shocked platelet coupled with ROS-responsive nanomedicine for targeted treatment of thromboembolic disease. ACS Nano. 2023;17:6519–33.

Article  CAS  PubMed  Google Scholar 

Dhanesha N, Patel RB, Doddapattar P, Ghatge M, Flora GD, Jain M, et al. PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke. Blood. 2022;139:1234–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han W, Lou Y, Tang J, Zhang Y, Chen Y, Li Y, et al. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. Biochem J. 2001;357:127–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Chu S-F, Ai Q-D, Zhang Z, Guan F-F, Wang S-S, et al. CKLF1 aggravates focal cerebral ischemia injury at early stage partly by modulating microglia/macrophage toward M1 polarization through CCR4. Cell Mol Neurobiol. 2019;39:651–69.

Article  CAS  PubMed  Google Scholar 

Kong LL, Hu JF, Zhang W, Yuan YH, Han N, Chen NH. C19, a C-terminal peptide of chemokine-like factor 1, protects the brain against focal brain ischemia in rats. Neurosci Lett. 2012;508:13–6.

Article  CAS  PubMed  Google Scholar 

Kong LL, Wang ZY, Han N, Zhuang XM, Wang ZZ, Li H, et al. Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats. J Neuroinflammation. 2014;11:112.

Article  PubMed  PubMed Central  Google Scholar 

Chen C, Chu SF, Ai QD, Zhang Z, Chen NH. CKLF1/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia. Int Immunopharmacol. 2020;85:106577.

Article  CAS  PubMed  Google Scholar 

Kong LL, Wang ZY, Hu JF, Yuan YH, Li H, Chen NH. Inhibition of chemokine-like factor 1 improves blood-brain barrier dysfunction in rats following focal cerebral ischemia. Neurosci Lett. 2016;627:192–8.

Article  CAS  PubMed  Google Scholar 

Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, et al. CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction. Autophagy. 2024;20:590–613.

Article  CAS  PubMed  Google Scholar 

Li G, Wang D, Sun M, Li G, Hu J, Zhang Y, et al. Discovery and optimization of novel 3-piperazinylcoumarin antagonist of chemokine-like factor 1 with oral antiasthma activity in mice. J Med Chem. 2010;53:1741–54.

Article  CAS  PubMed  Google Scholar 

Ai QD, Chen C, Chu S, Zhang Z, Luo Y, Guan F, et al. IMM-H004 therapy for permanent focal ischemic cerebral injury via CKLF1/CCR4-mediated NLRP3 inflammasome activation. Transl Res. 2019;212:36–53.

Article  CAS  PubMed  Google Scholar 

Song XY, Hu JF, Sun MN, Li ZP, Zhu ZX, Song LK, et al. IMM-H004, a novel coumarin derivative compound, attenuates the production of inflammatory mediatory mediators in lipopolysaccharide-activated BV2 microglia. Brain Res Bull. 2014;106:30–8.

Article  CAS  PubMed  Google Scholar 

Zuo W, Chen J, Zhang S, Tang J, Liu H, Zhang D, et al. IMM-H004 prevents toxicity induced by delayed treatment of tPA in a rat model of focal cerebral ischemia involving PKA-and PI3K-dependent Akt activation. Eur J Neurosci. 2014;39:2107–18.

Article  PubMed  Google Scholar 

Zuo W, Zhang W, Han N, Chen NH. Compound IMM-H004, a novel coumarin derivative, protects against CA1 cell loss and spatial learning impairments resulting from transient global ischemia. CNS Neurosci Ther. 2015;21:280–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Niu F, Song XY, Hu JF, Zuo W, Kong LL, Wang XF, et al. IMM-H004, a new coumarin derivative, improved focal cerebral ischemia via blood-brain barrier protection in rats. J Stroke Cerebrovasc Dis. 2017;26:2065–73.

Article  PubMed  Google Scholar 

Chen C, Ai Q, Chu S, Zhang Z, Zhou X, Luo P, et al. IMM-H004 protects against oxygen-glucose deprivation/reperfusion injury to BV2 microglia partly by modulating CKLF1 involved in microglia polarization. Int Immunopharmacol. 2019;70:69–79.

Article  CAS  PubMed  Google Scholar 

Ai Q, Chen C, Chu S, Luo Y, Zhang Z, Zhang S, et al. IMM-H004 protects against cerebral ischemia injury and cardiopulmonary complications via CKLF1 mediated inflammation pathway in adult and aged rats. Int J Mol Sci. 2019;20:1661.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang C, Pei A, Chen J, Yu H, Sun ML, Liu CF, et al. A natural coumarin derivative esculetin offers neuroprotection on cerebral ischemia/reperfusion injury in mice. J Neurochem. 2012;121:1007–13.

Article  CAS  PubMed  Google Scholar 

Liang S, Chen Z, Li H, Cang Z, Yin K, Wu M, et al. Neuroprotective effect of umbelliferone against cerebral ischemia/reperfusion induced neurological deficits: in-vivo and in-silico studies. J Biomol Struct Dyn. 2021;39:4715–25.

Article  CAS  PubMed  Google Scholar 

Connell BJ, Saleh MC, Rajagopal D, Saleh TM. UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia/reperfusion. Food Chem Toxicol. 2017;100:175–82.

Article  CAS  PubMed  Google Scholar 

Wu QL, Cui LY, Ma WY, Wang SS, Zhang Z, Feng ZP, et al. A novel small-molecular CCR5 antagonist promotes neural repair after stroke. Acta Pharmacol Sin. 2023;44:1935–47.

Article  CAS  PubMed  Google Scholar 

Chen J, Sanberg PR, Li Y, Wang L, Lu M, Willing AE, et al. Intravenous administration of human umbilical cord blood reduces behavioral def

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