bureau Pr. 2012 World population data sheet2012. Available from: https://www.prb.org/wp-content/uploads/2012/07/2012-population-data-sheet_eng.pdf.

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10.

alliance.org gs. WHAT IS SEPSIS? – DEFINITION OF SEPSIS 2021 [Available from: https://www.global-sepsis-alliance.org/sepsis.

Ibarz M, Haas LEM, Ceccato A, Artigas A. The critically ill older patient with sepsis: a narrative review. Ann Intensive Care. 2024;14(1):6.

Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395(10219):200-11.

de Groot B, Stolwijk F, Warmerdam M, Lucke JA, Singh GK, Abbas M, et al. The most commonly used disease severity scores are inappropriate for risk stratification of older emergency department sepsis patients: an observational multi-centre study. Scand J Trauma Resusc Emerg Med. 2017;25(1):91.

Boonmee P, Ruangsomboon O, Limsuwat C, Chakorn T. Predictors of Mortality in Elderly and Very Elderly Emergency Patients with Sepsis: A Retrospective Study. West J Emerg Med. 2020;21(6):210-8.

Zelis N, Buijs J, de Leeuw PW, van Kuijk SMJ, Stassen PM. A new simplified model for predicting 30-day mortality in older medical emergency department patients: The rise up score. Eur J Intern Med. 2020;77:36-43.

Sanguanwit P, Yuksen C, Khorana J, Phootothum Y, Damdin S, Sutham K. Factors for predicting 28-day mortality in older patients with suspected of having sepsis in the emergency department. Hong Kong Journal of Emergency Medicine. 31: 143-53.

Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644-55.

Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31(4):1250-6.

Lopansri BK, Miller Iii RR, Burke JP, Levy M, Opal S, Rothman RE, et al. Physician agreement on the diagnosis of sepsis in the intensive care unit: estimation of concordance and analysis of underlying factors in a multicenter cohort. J Intensive Care. 2019;7:13.

Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. 2017;45(3):486-552.

Ittisanyakorn M, Ruchichanantakul S, Vanichkulbodee A, Sri-On J. Prevalence and factors associated with one-year mortality of infectious diseases among elderly emergency department patients in a middle-income country. BMC Infect Dis. 2019;19(1):662.

Nasa P, Juneja D, Singh O. Severe sepsis and septic shock in the elderly: An overview. World J Crit Care Med. 2012;1(1):23-30.

Martin-Loeches I, Guia MC, Vallecoccia MS, Suarez D, Ibarz M, Irazabal M, et al. Risk factors for mortality in elderly and very elderly critically ill patients with sepsis: a prospective, observational, multicenter cohort study. Ann Intensive Care. 2019;9(1):26.

Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Critical Care Medicine. 2021;49(11).

Bruno RR, Wernly B, Mamandipoor B, Rezar R, Binnebössel S, Baldia PH, et al. ICU-Mortality in Old and Very Old Patients Suffering From Sepsis and Septic Shock. Frontiers in Medicine. 2021;8.

Arabi Y, Al Shirawi N, Memish Z, Venkatesh S, Al-Shimemeri A. Assessment of six mortality prediction models in patients admitted with severe sepsis and septic shock to the intensive care unit: a prospective cohort study. Crit Care. 2003;7(5):R116-22.

Chen CC, Chong CF, Liu YL, Chen KC, Wang TL. Risk stratification of severe sepsis patients in the emergency department. Emerg Med J. 2006;23(4):281-5.

Prachanukool T, Sanguanwit P, Thodamrong F, Suttapanit K. The 28-Day Mortality Outcome of the Complete Hour-1 Sepsis Bundle in the Emergency Department. Shock. 2021;56(6):969-74.

Suttapanit K, Wisan M, Sanguanwit P, Prachanukool T. Prognostic Accuracy of VqSOFA for Predicting 28-day Mortality in Patients with Suspected Sepsis in the Emergency Department. Shock. 2021;56(3):368-73.

Beesley SJ, Wilson EL, Lanspa MJ, Grissom CK, Shahul S, Talmor D, et al. Relative Bradycardia in Patients With Septic Shock Requiring Vasopressor Therapy. Crit Care Med. 2017;45(2):225-33.

Taccone FS, Artigas AA, Sprung CL, Moreno R, Sakr Y, Vincent JL. Characteristics and outcomes of cancer patients in European ICUs. Crit Care. 2009;13(1):R15.

Remelli F, Castellucci F, Vitali A, Mattioli I, Zurlo A, Spadaro S, et al. Predictive value of geriatric-quickSOFA in hospitalized older people with sepsis. BMC Geriatrics. 2021;21(1):241.

Jiang X, Khan FA, Ow MQ, Poh HMN. Sepsis in a Combined Medical and Surgical High Dependency/Intensive Care Unit in Singapore: A Cohort Study and Survival Analysis. Int J Gen Med. 2022;15:4585-93.

Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, et al. Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit: The Oxygen-ICU Randomized Clinical Trial. JAMA. 2016;316(15):1583-9.

Demiselle J, Wepler M, Hartmann C, Radermacher P, Schortgen F, Meziani F, et al. Hyperoxia toxicity in septic shock patients according to the Sepsis-3 criteria: a post hoc analysis of the HYPER2S trial. Ann Intensive Care. 2018;8(1):90.

Levy MM, Evans LE, Rhodes A. The Surviving Sepsis Campaign Bundle: 2018 Update. Critical Care Medicine. 2018;46(6):997-1000.

Ismail F, Mackay WG, Kerry A, Staines H, Rooney KD. The accuracy and timeliness of a Point Of Care lactate measurement in patients with Sepsis. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2015;23(1):68.

Asiimwe SB, Abdallah A, Ssekitoleko R. A simple prognostic index based on admission vital signs data among patients with sepsis in a resource-limited setting. Critical Care. 2015;19(1):86.

Karlsson A, Stassen W, Loutfi A, Wallgren U, Larsson E, Kurland L. Predicting mortality among septic patients presenting to the emergency department-a cross sectional analysis using machine learning. BMC Emerg Med. 2021;21(1):84.

Yang Y, Liang S, Geng J, Wang Q, Wang P, Cao Y, et al. Development of a nomogram to predict 30-day mortality of patients with sepsis-associated encephalopathy: a retrospective cohort study. Journal of Intensive Care. 2020;8(1):45.