A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders – a systematic review

Lipps H-J, Postberg J, Jackson DA (2010) Epigenetics, Disease and Behaviour, vol 48. Portland Press, London

Google Scholar 

Aging and health [https://www.who.int/news-room/fact-sheets/detail/aging-and-health]

Piefke M, Onur OA, Fink GR (2012) Aging-related changes of neural mechanisms underlying visual-spatial working memory. Neurobiol Aging 33(7):1284–1297

Article  PubMed  Google Scholar 

Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153(6):1194–1217

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lessel D, Kubisch C (2019) Hereditary Syndromes with Signs of Premature Aging. Dtsch Arztebl Int 116(29–30):489–496

PubMed  PubMed Central  Google Scholar 

Schnabel F, Kornak U, Wollnik B (2021) Premature aging disorders: A clinical and genetic compendium. Clin Genet 99(1):3–28

Article  CAS  PubMed  Google Scholar 

Darrow SM, Verhoeven JE, Révész D, Lindqvist D, Penninx BW, Delucchi KL, Wolkowitz OM, Mathews CA (2016) The Association Between Psychiatric Disorders and Telomere Length: A Structured review Involving 14,827 Persons. Psychosom Med 78(7):776–787

Article  PubMed  PubMed Central  Google Scholar 

Wertz J, Caspi A, Ambler A, Broadbent J, Hancox RJ, Harrington H, Hogan S, Houts RM, Leung JH, Poulton R et al (2021) Association of History of Psychopathology With Accelerated Aging at Midlife. JAMA Psychiat 78(5):530–539

Article  Google Scholar 

Walker ER, McGee RE, Druss BG (2015) Mortality in mental disorders and global disease burden implications: a systematic review and structured review. JAMA Psychiat 72(4):334–341

Article  Google Scholar 

Booth LN, Brunet A (2016) The Aging Epigenome. Mol Cell 62(5):728–744

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang W, Qu J, Liu GH, Belmonte JCI (2020) The aging epigenome and its rejuvenation. Nat Rev Mol Cell Biol 21(3):137–150

Article  CAS  PubMed  Google Scholar 

Postberg J, Lipps HJ, Cremer T (2010) Evolutionary origin of the cell nucleus and its functional architecture. Essays Biochem 48(1):1–24

CAS  PubMed  Google Scholar 

Bird AP (1986) CpG-rich islands and the function of DNA methylation. Nature 321(6067):209–213

Article  CAS  PubMed  Google Scholar 

Biliya S, Bulla LA Jr (2010) Genomic imprinting: the influence of differential methylation in the two sexes. Exp Biol Med (Maywood) 235(2):139–147

Article  CAS  PubMed  Google Scholar 

Hackett JA, Surani MA (2013) DNA methylation dynamics during the mammalian life cycle. Philos Trans R Soc Lond B Biol Sci 368(1609):20110328

Article  PubMed  PubMed Central  Google Scholar 

Hermann A, Gowher H, Jeltsch A (2004) Biochemistry and biology of mammalian DNA methyltransferases. Cell Mol Life Sci 61(19–20):2571–2587

Article  CAS  PubMed  Google Scholar 

Hirasawa R, Feil R (2010) Genomic imprinting and human disease. Essays Biochem 48(1):187–200

CAS  PubMed  Google Scholar 

Smith ZD, Meissner A (2013) DNA methylation: roles in mammalian development. Nat Rev Genet 14(3):204–220

Article  CAS  PubMed  Google Scholar 

Roth TL, Roth ED, Sweatt JD (2010) Epigenetic regulation of genes in learning and memory. Essays Biochem 48(1):263–274

CAS  PubMed  Google Scholar 

McGowan PO, Szyf M (2010) Environmental epigenomics: understanding the effects of parental care on the epigenome. Essays Biochem 48(1):275–287

CAS  PubMed  Google Scholar 

Jones MJ, Goodman SJ, Kobor MS (2015) DNA methylation and healthy human aging. Aging Cell 14(6):924–932

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murgatroyd C, Wu Y, Bockmühl Y, Spengler D (2010) The Janus face of DNA methylation in aging. Aging (Albany NY) 2(2):107–110

Article  CAS  PubMed  Google Scholar 

Bocklandt S, Lin W, Sehl ME, Sánchez FJ, Sinsheimer JS, Horvath S, Vilain E (2011) Epigenetic predictor of age. PLoS ONE 6(6):e14821

Article  CAS  PubMed  PubMed Central  Google Scholar 

Horvath S, Raj K (2018) DNA methylation-based biomarkers and the epigenetic clock theory of aging. Nat Rev Genet 19(6):371–384

Article  CAS  PubMed  Google Scholar 

Oblak L, van der Zaag J, Higgins-Chen AT, Levine ME, Boks MP (2021) A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration. Aging Res Rev 69:101348

Article  CAS  Google Scholar 

Horvath S (2013) DNA methylation age of human tissues and cell types. Genome Biol 14(10):R115

Article  PubMed  PubMed Central  Google Scholar 

Horvath S (2015) Erratum to: DNA methylation age of human tissues and cell types. Genome Biol 16(1):96

Article  PubMed  PubMed Central  Google Scholar 

Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S, Klotzle B, Bibikova M, Fan JB, Gao Y et al (2013) Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell 49(2):359–367

Article  CAS  PubMed  Google Scholar 

Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y et al (2018) An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY) 10(4):573–591

Article  PubMed  Google Scholar 

Liu C, Jiao C, Wang K, Yuan N (2018) DNA Methylation and Psychiatric Disorders. Prog Mol Biol Transl Sci 157:175–232

Article  CAS  PubMed  Google Scholar 

Grodstein F, Lemos B, Yu L, Klein HU, Iatrou A, Buchman AS, Shireby GL, Mill J, Schneider JA, De Jager PL et al (2021) The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes. Neurobiol Dis 157:105428

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moola S, Munn Z, Tufanuru C, Aromataris E, Sears K, Sfetcu R, Currie M, Lisy K, Qureshi R, Mattis P, Mu PF (ed.) (2020) Chapter 7: Systematic reviews of etiology and risk: In: JBI Manual for Evidence Synthesis (https://synthesismanual.jbi.global): The Joanna Briggs Institute: ISBN 978-0-6488488-2-0: https://doi.org/10.46658/JBIMES-24-06

Schünemann H, Brożek J, Guyatt G, Oxman A (2013) GRADE handbook for grading quality of evidence and strength of recommendations. https://gdt.gradepro.org/app/handbook/handbook.html

Sterling TD (1959) Publication Decisions and their Possible Effects on Inferences Drawn from Tests of Significance—or Vice Versa. J Am Stat Assoc 54(285):30–34

Google Scholar 

Meerpohl JJ, Langer G, Perleth M, Gartlehner G, Kaminski-Hartenthaler A, Schünemann H (2012) GRADE guidelines: 3. Rating the quality of evidence (confidence in the estimates of effect). Z Evid Fortbild Qual Gesundhwes 106(6):449–456

Article  PubMed  Google Scholar 

Fries GR, Bauer IE, Scaini G, Valvassori SS, Walss-Bass C, Soares JC, Quevedo J (2020) Accelerated hippocampal biological aging in bipolar disorder. Bipolar Disord 22(5):498–507

Article  CAS  PubMed 

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