RNAseq-based transcriptomics of treatment-naïve multi-inflammatory syndrome in children (MIS-C) demonstrates predominant activation of matrisome, innate and humoral immune pathways

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y et al (2020) Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet 395(10223):507–513

Article  CAS  Google Scholar 

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet 395(10229):1054–1062

Article  CAS  Google Scholar 

Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P (2020) Hyperinflammatory shock in children during COVID-19 pandemic. The Lancet 395(10237):1607–1608

Article  CAS  Google Scholar 

Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J et al (2020) Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 370(6515):4570

Article  Google Scholar 

Consiglio CR, Cotugno N, Sardh F, Pou C, Amodio D, Rodriguez L et al (2020) The immunology of multisystem inflammatory syndrome in children with COVID-19. Cell 183(4):968-981.e7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gruber CN, Patel RS, Trachtman R, Lepow L, Amanat F, Krammer F et al (2020) Mapping systemic inflammation and antibody responses in multisystem inflammatory syndrome in children (MIS-C). Cell 183(4):982-995.e14

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee PY, Platt CD, Weeks S, Grace RF, Maher G, Gauthier K et al (2020) Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. J Allergy Clin Immunol 146(5):1194-1200.e1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chou J, Platt CD, Habiballah S, Nguyen AA, Elkins M, Weeks S et al (2021) Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C). J Allergy Clin Immunol 148(3):732-738.e1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19 [Internet]. https://www.who.int/news-room/commentaries/detail/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19. Cited 25 Dec 2022

Rowley AH, Wylie KM, Kim KYA, Pink AJ, Yang A, Reindel R et al (2015) The transcriptional profile of coronary arteritis in Kawasaki disease. BMC Genom 18(16):1076

Article  Google Scholar 

Babraham Bioinformatics-FastQC a quality control tool for high throughput sequence data [Internet]. https://www.bioinformatics.babraham.ac.uk/projects/fastqc/. Cited 25 Dec 2022

Ewels P, Magnusson M, Lundin S, Käller M (2016) MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics 32(19):3047–3048

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S et al (2013) STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29(1):15–21

Article  CAS  PubMed  Google Scholar 

Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15(12):550

Article  PubMed  PubMed Central  Google Scholar 

Patnaik S, Jain MK, Ahmed S, Dash AK, Ram KP, Sahoo B et al (2021) Short-term outcomes in children recovered from multisystem inflammatory syndrome associated with SARS-CoV-2 infection. Rheumatol Int 41(11):1957–1962

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jones TC, Mühlemann B, Veith T, Biele G, Zuchowski M, Hofmann J et al (2020) An analysis of SARS-CoV-2 viral load by patient age. Infect Dis (Except HIV/AIDS). https://doi.org/10.1101/2020.06.08.20125484

Article  Google Scholar 

Brodin P (2020) Why is COVID-19 so mild in children? Acta Paediatr 109(6):1082–1083

Article  CAS  PubMed  Google Scholar 

Acevedo L, Piñeres-Olave BE, Niño-Serna LF, Vega LM, Gomez IJA, Chacón S et al (2021) Mortality and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) associated with covid-19 in critically ill patients: an observational multicenter study (MISCO study). BMC Pediatr 21(1):516

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baimukhamedov C, Mirakhmedova K, Dossybayeva G (2023) Long COVID: the time has come for globally acceptable definitions. Rheumatol Int 43:2155–2156

Article  PubMed  Google Scholar 

Kouranloo K, Dey M, Elwell H, Nune A (2023) A systematic review of the incidence, management and prognosis of new-onset autoimmune connective tissue diseases after COVID-19. Rheumatol Int 43(7):1221–1243

Article  PubMed  PubMed Central  Google Scholar 

Jiang J, Cai Y, Li Z, Huang L, Chen J, Tian L et al (2017) Screening of differentially expressed genes associated with Kawasaki disease by microarray analysis. Exp Ther Med 14(4):3159–3164

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang C, Kho YS, Wang Z, Chiang YT, Ng GKH, Shaw PC et al (2014) Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum. PLoS ONE 9(1):e85206

Article  PubMed  PubMed Central  Google Scholar 

Ye YP, Jiao HL, Wang SY, Xiao ZY, Zhang D, Qiu JF et al (2018) Hypermethylation of DMTN promotes the metastasis of colorectal cancer cells by regulating the actin cytoskeleton through Rac1 signaling activation. J Exp Clin Cancer Res CR 37(1):299

Article  CAS  PubMed  Google Scholar 

Anguita E, Candel FJ, Chaparro A, Roldán-Etcheverry JJ (2017) Transcription factor GFI1B in health and disease. Front Oncol 7:54

Article  PubMed  PubMed Central  Google Scholar 

Beauchemin H, Shooshtarizadeh P, Vadnais C, Vassen L, Pastore YD, Möröy T (2017) Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes. Haematologica 102(3):484–497

Article  CAS  PubMed  PubMed Central  Google Scholar 

Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices*. Mol Cell Proteom 11(4):M111.014647

Article  Google Scholar 

NABA_MATRISOME [Internet]. https://www.gsea-msigdb.org/gsea/msigdb/cards/NABA_MATRISOME. Cited 13 Apr 2023

Sacco K, Castagnoli R, Vakkilainen S, Liu C, Delmonte OM, Oguz C et al (2022) Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19. Nat Med 28(5):1050–1062

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuzhalin AE, Lim SY, Kutikhin AG, Gordon-Weeks AN (2018) Dynamic matrisome: ECM remodeling factors licensing cancer progression and metastasis. Biochim Biophys Acta Rev Cancer 1870(2):207–228

Article  CAS  PubMed  Google Scholar 

Hynes RO, Naba A (2012) Overview of the matrisome—an inventory of extracellular matrix constituents and functions. Cold Spring Harb Perspect Biol 4(1):a004903

Article  PubMed  PubMed Central  Google Scholar 

Lobo Rodríguez C, López-Calleja AM, de Los M, Ríos Luna P, Sánchez Vázquez S, Molinero Sampedro Á, López-Esteban A (2023) Comparison of the first and sixth waves of the SARS-COV-2 coronavirus pandemic in patients with immune-mediated disease. Reumatol Clin. https://doi.org/10.1016/j.reumae.2023.02.011

Article  PubMed  PubMed Central  Google Scholar 

Benny L, Mehta P, Ahmed S, Paul A, Sukumaran A, Mohanan M et al (2023) Correlates of breakthrough Omicron (B.1.1.529) infections in a prospective cohort of vaccinated patients with rheumatic diseases. Rheumatol Int 43(6):1033–1039

Article  PubMed  PubMed Central 

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