Morata G, Ripoll P (1975) Minutes — mutants of Drosophila autonomously affecting cell-division rate. Dev Biol 42(2):211–221. https://doi.org/10.1016/0012-1606(75)90330-9
Article CAS PubMed Google Scholar
Van Neerven SM, Vermeulen L (2023) Cell competition in development, homeostasis and cancer. Nat Rev Mol Cell Biol 24(3):221–236. https://doi.org/10.1038/s41580-022-00538-y
Article CAS PubMed Google Scholar
Maruyama T, Fujita Y (2017) Cell competition in mammals — novel homeostatic machinery for embryonic development and cancer prevention. Curr Opin Cell Biol 48:106–112. https://doi.org/10.1016/j.ceb.2017.06.007
Article CAS PubMed Google Scholar
Maruyama T, Fujita Y (2022) Cell competition in vertebrates—a key machinery for tissue homeostasis. Curr Opin Genet Dev 72:15–21. https://doi.org/10.1016/j.gde.2021.09.006
Article CAS PubMed Google Scholar
Hogan C, Dupré-Crochet S, Norman M et al (2009) Characterization of the interface between normal and transformed epithelial cells. Nat Cell Biol 11(4):460–467. https://doi.org/10.1038/ncb1853
Article CAS PubMed Google Scholar
Kajita M, Hogan C, Harris AR et al (2010) Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells. J Cell Sci 123(2):171–180. https://doi.org/10.1242/jcs.057976
Article CAS PubMed Google Scholar
Wagstaff L, Goschorska M, Kozyrska K et al (2016) Mechanical cell competition kills cells via induction of lethal p53 levels. Nat Commun 7. https://doi.org/10.1038/ncomms11373
Tamori Y, Bialucha CU, Tian AG et al (2010) Involvement of Lgl and Mahjong/VprBP in cell competition. Plos Biol 8 (7). https://doi.org/10.1371/journal.pbio.1000422
Chiba T, Ishihara E, Miyamura N, R. Narumi et al (2016) MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status. Sci Rep 6. https://doi.org/10.1038/srep28383
Moya IM, Castaldo SA, Van den Mooter L et al (2019) Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science 366(6468):1029–1034. https://doi.org/10.1126/science.aaw9886
Article CAS PubMed Google Scholar
Alcolea MP, Jones PH (2015) Cell competition: winning out by losing notch. Cell Cycle 14(1):9–17. https://doi.org/10.4161/15384101.2014.988027
Article CAS PubMed PubMed Central Google Scholar
Kon S, Ishibashi K, Katoh H et al (2017) Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. Nat Cell Biol 19(5):530–541. https://doi.org/10.1038/ncb3509
Article CAS PubMed Google Scholar
Sasaki A, Nagatake T, Egami R et al (2018) Obesity suppresses cell-competition-mediated apical elimination of RasV12-transformed cells from epithelial tissues. Cell Rep 23(4):974–982. https://doi.org/10.1016/j.celrep.2018.03.104
Article CAS PubMed PubMed Central Google Scholar
Ayukawa S, Kamoshita N, Nakayama J et al (2021) Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction. Nat Immunol 22(11):1391–1402. https://doi.org/10.1038/s41590-021-01045-6
Article CAS PubMed Google Scholar
Takai T (2005) Paired immunoglobulin-like receptors and their MHC class I recognition. Immunology 115(4):433–440. https://doi.org/10.1111/j.1365-2567.2005.02177.x
Article CAS PubMed PubMed Central Google Scholar
Yoshihama S, Vijayan S, Sidiq T, Kobayashi KS (2017) NLRC5/CITA: a key player in cancer immune surveillance. Trends in Cancer 3(1):28–38. https://doi.org/10.1016/j.trecan.2016.12.003
Article PubMed PubMed Central Google Scholar
Schwartz M, Portugez AS, Attia BZ et al (2020) Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation. Commun Biol 3 (1). https://doi.org/10.1038/s42003-020-01398-y
Yoh KE, Regunath K, Guzman A et al (2016) Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells. Proc Natl Acad Sci USA 113(41):E6107–E6116. https://doi.org/10.1073/pnas.1613417113
Article CAS PubMed PubMed Central Google Scholar
Franceschi RT, Xiao GZ (2003) Regulation of the osteoblast-specific transcription factor, runx2: responsiveness to multiple signal transduction pathways. J Cell Biochem 88(3):446–454. https://doi.org/10.1002/jcb.10369
Article CAS PubMed Google Scholar
Held W, Mariuzza RA (2008) Cis interactions of immunoreceptors with MHC and non-MHC ligands. Nat Rev Immunol 8(4):269–278. https://doi.org/10.1038/nri2278
Article CAS PubMed PubMed Central Google Scholar
Shiroishi M, Kuroki K, Rasubala L et al (2006) Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d). Proc Natl Acad Sci USA 103(44):16412–16417. https://doi.org/10.1073/pnas.0605228103
Article CAS PubMed PubMed Central Google Scholar
Hill W, Zaragkoulias A, Salvador-Barbero B et al (2021) EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas. Curr Biol 31(12):2550–2560. https://doi.org/10.1016/j.cub.2021.03.094
Article CAS PubMed PubMed Central Google Scholar
Porazinski S, de Navascués J, Yako Y et al (2016) EphA2 drives the segregation of Ras-transformed epithelial cells from normal neighbors. Curr Biol 26(23):3220–3229. https://doi.org/10.1016/j.cub.2016.09.037
Article CAS PubMed Google Scholar
Hill W, Hogan C (2019) Normal epithelial cells trigger EphA2-dependent RasV12 cell repulsion at the single cell level. Small GTPases 10(4):305–310. https://doi.org/10.1080/21541248.2017.1324940
Article CAS PubMed Google Scholar
Nakamoto M, Cheng HJ, Friedman GC et al (1996) Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell 86(5):755–766. https://doi.org/10.1016/s0092-8674(00)80150-6
Article CAS PubMed Google Scholar
Mori Y, Shiratsuchi N, Sato N et al (2022) Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition or apoptosis. Curr Biol 32(10):2144–2159. https://doi.org/10.1016/j.cub.2022.03.057
Article CAS PubMed Google Scholar
Ogawa M, Kawarazaki Y, Fujita Y et al (2021) FGF21 induced by the ASK1-p38 pathway promotes mechanical cell competition by attracting cells. Curr Biol 31 (5). https://doi.org/10.1016/j.cub.2020.11.052
Gu YP, Forostyan T, Sabbadini R, Rosenblatt J (2011) Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway. J Cell Biol 193(4):667–676. https://doi.org/10.1083/jcb.201010075
Article CAS PubMed PubMed Central Google Scholar
Yamamoto S, Yako Y, Fujioka Y et al (2016) A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC). Mol Biol Cell 27(3):491–499. https://doi.org/10.1091/mbc.E15-03-0161
Article CAS PubMed PubMed Central Google Scholar
Kajita M, Sugimura K, Ohoka A et al (2014) Filamin acts as a key regulator in epithelial defence against transformed cells. Nature Communication 5:4428. https://doi.org/10.1038/ncomms5428
Hamidouche Z, Fromigué O, Ringe J et al (2009) Priming integrin α5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. Proc Natl Acad Sci USA 106(44):18587–18591. https://doi.org/10.1073/pnas.0812334106
Comments (0)