Chambers DC, Cherikh WS, Goldfarb SB, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth adult lung and heart-lung transplant report-2018; Focus theme: Multiorgan Transplantation. J Heart Lung Transplant. 2018;37:1169–83. https://doi.org/10.1016/j.healun.2018.07.020.

Article  PubMed  Google Scholar 

Todd JL, Neely ML, Kopetskie H, et al. Risk factors for acute rejection in the first year after lung transplant. A multicenter study. Am J Respir Crit Care Med. 2020;202(4):576–85.

Article  PubMed  PubMed Central  Google Scholar 

Trulock EP, Christie JD, Edwards LB, et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult lung and heart-lung transplantation report-2007. J Heart Lung Transplant. 2007;26(8):782–95.

Article  PubMed  Google Scholar 

Calabrese F, Roden AC, Pavlisko E, Lunardi F, Neil D, Adam B, Hwang D, Goddard M, Berry GJ, Ivanovic M, Thüsen JV, Gibault L, Lin CY, Wassilew K, Glass C, Westall G, Zeevi A, Levine DJ, Roux A. Lung allograft standardized histological analysis (LASHA) template: a research consensus proposal. J Heart Lung Transplant. 2022;41(10):1487–500. https://doi.org/10.1016/j.healun.2022.06.021. Epub 2022 Jul 3.

Article  PubMed  Google Scholar 

Burton CM, Iversen M, Carlsen J, et al. Acute cellular rejection is a risk factor for bronchiolitis obliterans syndrome independent of post-transplant baseline FEV1. J Heart Lung Transplant. 2009;28(9):888–93.

Article  PubMed  Google Scholar 

Girnita AL, McCurry KR, Iacono AT, et al. HLA-specific antibodies are associated with high-grade and persistent-recurrent lung allograft acute rejection. J Heart Lung Transplant. 2004;23:1135–41.

Article  PubMed  Google Scholar 

Avtaar Singh SS, De Das S, Al-Adhami A, Singh R, Hopkins PM, Curry PA. Primary graft dysfunction following lung transplantation: from pathogenesis to future frontiers. World J Transplant. 2023;13(3):58–85. https://doi.org/10.5500/wjt.v13.i3.58.

Article  PubMed  PubMed Central  Google Scholar 

Garces JC, Giusti S, Staffeld-Coit C, Bohorquez H, Cohen AJ, Loss GE. Antibody-Mediated Rejection: A Review. Ochsner J. 2017;17(1):46–55.

PubMed  PubMed Central  Google Scholar 

•• Bery AI, Hachem RR. Antibody-mediated rejection after lung transplantation. Ann Transl Med. 2020;8(6):411. https://doi.org/10.21037/atm.2019.11.86. This paper gives a very good overview of AMR and discusses some of the latest developments with regards to diagnosing AMR and discusses some of the latest therapeutics that are promising for treating AMR.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frost AE, Jammal CT, Cagle PT. Hyperacute rejection following lung transplantation. Chest. 1996;110:559–62.

Article  CAS  PubMed  Google Scholar 

Kulkarni HS, Bemiss BC, Hachem RR. Antibody-mediated rejection in lung transplantation. Curr Transplant Rep. 2015;2:316–23.

Article  PubMed  PubMed Central  Google Scholar 

Badesch DB, Zamora M, Fullerton D, et al. Pulmonary capillaritis: a possible histologic form of acute pulmonary allograft rejection. J Heart Lung Transplant. 1998;17:415–22.

CAS  PubMed  Google Scholar 

Magro CM, Deng A, Pope-Harman A, et al. Humorally mediated posttransplantation septal capillary injury syndrome as a common form of pulmonary allograft rejection: a hypothesis. Transplantation. 2002;74:1273–80.

Article  CAS  PubMed  Google Scholar 

Otani S, Davis AK, Cantwell L, et al. Evolving experience of treating antibody-mediated rejection following lung transplantation. Transpl Immunol. 2014;31:75–80.

Article  CAS  PubMed  Google Scholar 

Witt CA, Gaut JP, Yusen RD, et al. Acute antibody-mediated rejection after lung transplantation. J Heart Lung Transplant. 2013;32:1034–40. https://doi.org/10.1016/j.healun.2013.07.004.

Article  PubMed  Google Scholar 

Thomas KA, Valenzuela NM, Reed EF. The perfect storm: HLA antibodies, complement, FcγRs, and endothelium in transplant rejection. Trends Mol Med. 2015;21(5):319–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murata K, Baldwin WM 3rd. Mechanisms of complement activation, C4d deposition, and their contribution to the pathogenesis of antibody-mediated rejection. Transplant Rev (Orlando). 2009;23(3):139–50.

Article  PubMed  Google Scholar 

Bos S, Milross L, Filby AJ, Vos R, Fisher AJ. Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle. Eur Respir Rev. 2022;31(165):220060.

Article  PubMed  PubMed Central  Google Scholar 

Nunoda S. Impact of pretransplant antibodies on outcomes after heart transplantation. Curr Opin Organ Transplant. 2019;24(3):220–6.

Article  PubMed  PubMed Central  Google Scholar 

Roux A, Le Lan IB, Holifanjaniaina S, et al. Antibody-mediated rejection in lung transplantation: clinical outcomes and donor-specific antibody characteristics. Am J Transplant. 2016;16:1216–28.

Article  CAS  PubMed  Google Scholar 

Angaswamy N, Tiriveedhi V, Sarma NJ, et al. Interplay between immune responses to HLA and non-HLA self-antigens in allograft rejection. Hum Immunol. 2013;74:1478–85.

Article  CAS  PubMed  Google Scholar 

Tikkanen JM, Singer LG, Kim SJ, Li Y, Binnie M, Chaparro C, Chow CW, Martinu T, Azad S, Keshavjee S, Tinckam K. De Novo DQ Donor-specific antibodies are associated with chronic lung allograft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2016;194(5):596–606.

Article  CAS  PubMed  Google Scholar 

Snyder LD, Wang Z, Chen DF, Reinsmoen NL, Finlen-Copeland CA, Davis WA, Zaas DW, Palmer SM. Implications for human leukocyte antigen antibodies after lung transplantation: a 10-year experience in 441 patients. Chest. 2013;144(1):226–33.

Article  PubMed  PubMed Central  Google Scholar 

Morrell MR, Pilewski JM, Gries CJ, Pipeling MR, Crespo MM, Ensor CR, Yousem SA, D’Cunha J, Shigemura N, Bermudez CA, McDyer JF, Zeevi A. De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation. J Heart Lung Transplant. 2014;33(12):1288–94.

Article  PubMed  Google Scholar 

Smith JD, Banner NR, Hamour IM, Ozawa M, Goh A, Robinson D, Terasaki PI, Rose ML. De novo donor HLA-specific antibodies after heart transplantation are an independent predictor of poor patient survival. Am J Transplant. 2011;11(2):312–9.

Article  CAS  PubMed  Google Scholar 

Jackson JA, Kim EJ, Begley B, Cheeseman J, Harden T, Perez SD, Thomas S, Warshaw B, Kirk AD. Urinary chemokines CXCL9 and CXCL10 are noninvasive markers of renal allograft rejection and BK viral infection. Am J Transplant. 2011;11(10):2228–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hartono C, Muthukumar T, Suthanthiran M. Noninvasive diagnosis of acute rejection of renal allografts. Curr Opin Organ Transplant. 2010;15(1):35–41.

Article  PubMed  PubMed Central  Google Scholar 

Wood-Trageser MA, Lesniak AJ, Demetris AJ. Enhancing the value of histopathological assessment of allograft biopsy monitoring. Transplantation. 2019;103(7):1306–22.

Article  PubMed  PubMed Central  Google Scholar 

Süsal C, Opelz G, Morath C. Role and Value of Luminex(®)-Detected HLA Antibodies before and after Kidney Transplantation. Transfus Med Hemother. 2013;40(3):190–5. https://doi.org/10.1159/000351314. Epub 2013 May 6.

Article  PubMed  PubMed Central  Google Scholar 

Maguire O, Tario JD Jr, Shanahan TC, Wallace PK, Minderman H. Flow cytometry and solid organ transplantation: a perfect match. Immunol Invest. 2014;43(8):756–74.

Article  PubMed  PubMed Central  Google Scholar 

Scornik J. Detection of alloantibodies by flow cytometry: relevance to clinical transplantation. Cytometry. 1995;22:259–63.

Article  CAS  PubMed  Google Scholar 

Tait B, Hudson F, Cantwell L, et al. Review article: Luminex technology for HLA antibody detection in organ transplantation. Nephrol. 2009;14:247–54.

Article  CAS  PubMed  Google Scholar 

Lunardi F, Vedovelli L, Pezzuto F, et al. Assessing the role of phosphorylated S6 ribosomal protein in the pathological diagnosis of pulmonary antibody-mediated rejection. J Heart Lung Transplant. 2023.

Keller M, Agbor-Enoh S. Cell-free DNA in lung transplantation: research tool or clinical workhorse? Curr Opin Organ Transplant. 2022;27(3):177–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

• Khush KK, De Vlaminck I, Luikart H, et al. Donor-derived, cell-free DNA levels by next-generation targeted sequencing are elevated in allograft rejection after lung transplantation. ERJ Open Res. 2021;7(1). This study reviews the importance of cell-free DNA as a non-invasive marker that is detectable by assay, and may predict the onset of graft dysfunction due to AMR.

Agbor-Enoh S, Jackson AM, Tunc I, Berry GJ, Cochrane A, Grimm D, et al. Late manifestation of alloantibody-associated injury and clinical pulmonary antibody-mediated rejection: evidence from cell-free DNA analysis. J Heart Lung Transplant. 2018;37:925–32.

Article  PubMed  Google Scholar 

Jang MK, Tunc I, Berry GJ, et al. Donor-derived cell-free DNA accurately detects acute rejection in lung transplant patients, a multicenter cohort study. J Heart Lung Transplant. 2021;40(8):82283. https://doi.org/10.1016/j.healun.2021.04.009.

Article  Google Scholar