aCenter for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen N, Denmark

bCenter for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA

Correspondence to Maiken Nedergaard, MD, PhD, Professor of Neurology, University of Rochester, 601 Elmwood AveRochester, NY 14642, USA. Tel: +1 585 275 0550; e-mail: [email protected]