Global food production and plant breeding are continuously being revolutionized through innovations in food biotechnology. These advancements in biotechnology include a vast array of new genomic techniques (NGTs), including genome editing (GE), which specifically allows for targeted insertion, deletion, or substitution at a specific site of a gene without addition of foreign DNA [1]. Attributable to the precision of GE technology in targeting specific genome sites, the technology has exhibited more success during its development phase than other plant biotechnology techniques including genetic modification (GM) [2]. In the developing world, where adequate nutrition and food security are real challenges, especially in the wake of climate change, GE could be of particular interest [3]. This is because of its broad potential application in improving desirable traits of important cereal and staple crops 4•, 5. Despite its barriers and challenges from development to implementation, for example, off-target effects, lack of infrastructure in many geographical regions, intellectual property rights, legal and policy issues, lack of knowledge, and uncertainties concerning public acceptance [6], GE could present a timely, complementary tool for increased agricultural production and more sustainable agri-food systems 1, 7, 8. This review focuses on the implications of government regulations on genome-edited (GEd) foods and the stakeholder perceptions of these regulations, and further discusses consumer perceptions of GEd foods in comparison with genetically modified (GMd) foods.