Advances in Pharmacology and Pharmacy Vol. 12(2), pp. 125 - 134
DOI: 10.13189/app.2024.120205
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Swapnil S. Patil 1,2,*, Manojkumar M. Nitalikar 3, Preeti khulbe 1
1 Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India
2 Annasaheb Dange College of B. Pharmacy, Ashta, India
3 Rajarambapu College of Pharmacy, Kasegaon, India

ABSTRACT

The current study describes a green method to make silver nanoparticles from bixa orellana extract (BOAgNPs). The application of green synthesis for nanoparticle production is considered advantageous in comparison to alternative synthesis methods due to its environmentally friendly nature and cost-effectiveness. Extraction of Bixa orellana seed was carried out by hot extraction technique. The extract was then utilized to prepare silver nanoparticles. The study aimed to investigate the impact of process variables, specifically the concentration of silver nitrate (AgNO3) and stirring duration, on the particle size and entrapment efficiency of produced BOAgNPs. The ANNOVA of a quadratic model was applied using design expert software to assess the impacts. The optimized BOAgNPs were subjected to characterization using UV and FTIR. The quadratic model provided an optimal batch with a particle size of 88.5 nm and an entrapment efficiency of 95.73%. The observed zeta potential of -35.5 mV indicates that the formulation is likely to exhibit a high level of stability. The analysis of the quadratic model indicates that an increase in string duration results in a significantly increase in particle size. Additionally, an increase in the concentration of AgNO3 leads to an increase in the entrapment efficiency of BOAgNPs. Nanogel of optimized batch of BOAgNPs has evaluated with In vitro anticancer cell line and it reveals moderate activity against B16F10 cell line.

KEYWORDS
Extraction, Silver Nanoparticles, Design Expert, Optimization, Process Paramters

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Swapnil S. Patil , Manojkumar M. Nitalikar , Preeti khulbe , "Design, Development and Optimization of Bixa Orellana Extract Loaded Silver Nanoparticle," Advances in Pharmacology and Pharmacy, Vol. 12, No. 2, pp. 125 - 134, 2024. DOI: 10.13189/app.2024.120205.

(b). APA Format:
Swapnil S. Patil , Manojkumar M. Nitalikar , Preeti khulbe (2024). Design, Development and Optimization of Bixa Orellana Extract Loaded Silver Nanoparticle. Advances in Pharmacology and Pharmacy, 12(2), 125 - 134. DOI: 10.13189/app.2024.120205.