Coenzyme Q4 is a functional substitute for coenzyme Q10 and can be targeted to the mitochondria
KEYWORDS
Coenzyme Q10 (CoQ10)
Ubiquinone
Mitochondrial respiratory chain complex
Mitochondrial therapeutics
Membrane lipid
Bioenergetics
Antioxidant
Ferroptosis
Pyrimidine biosynthesis
ABBREVIATIONS AND NOMENCLATUREATP
adenosine triphosphate
DCFDA
dichlorodihydrofluorescein diacetate
DHODH
dihydrooratate dehydrogenase
DMEM
Dulbecco’s Modified Eagle Media
dPBS
Dulbecco’s phosphate buffered saline
ETC
electron transport chain
FCCP
Carbonyl cyanide p-trifluoro-methoxyphenyl hydrazone
HEPES
4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid
HPLC-ECD
high performance liquid chromatography – electrochemical detection
IMDM
Iscove’s Modified Dulbecco’s Medium
OxPhos
oxidative phosphorylation
PLE
porcine liver esterase
RIPA
radioimmunoprecipitation assay buffer
ROS
reactive oxygen species
© 2024 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.
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