Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48. https://doi.org/10.3322/caac.21763.
Moreno C. Standard treatment approaches for relapsed/refractory chronic lymphocytic leukemia after frontline chemoimmunotherapy. Hematol Am Soc Hematol Educ Program. 2020;2020(1):33–40. https://doi.org/10.1182/hematology.2020000086.
Woyach JA. Management of relapsed/refractory chronic lymphocytic leukemia. Am J Hematol. 2022;97(Suppl. 2):S11–8. https://doi.org/10.1002/ajh.26683.
Article PubMed PubMed Central Google Scholar
Raedler LA. Imbruvica (ibrutinib), first-in-class Bruton’s tyrosine kinase inhibitor, receives expanded indications for patients with relapsed chronic lymphocytic leukemia. Am Health Drug Benefits. 2015;8(Spec Future):66–9.
PubMed PubMed Central Google Scholar
Munir T, Brown JR, O’Brien S, Barrientos JC, Barr PM, Reddy NM, et al. Final analysis from RESONATE: up to six years of follow-up on ibrutinib in patients with previously treated chronic lymphocytic leukemia or small lymphocytic lymphoma. Am J Hematol. 2019;94(12):1353–63. https://doi.org/10.1002/ajh.25638.
Article CAS PubMed PubMed Central Google Scholar
Mato AR, Nabhan C, Thompson MC, Lamanna N, Brander DM, Hill B, et al. Toxicities and outcomes of 616 ibrutinib-treated patients in the United States: a real-world analysis. Haematologica. 2018;103(5):874–9. https://doi.org/10.3324/haematol.2017.182907.
Article CAS PubMed PubMed Central Google Scholar
Guo Y, Liu Y, Hu N, Yu D, Zhou C, Shi G, et al. Discovery of zanubrutinib (BGB-3111), a novel, potent, and selective covalent inhibitor of Bruton’s tyrosine kinase. J Med Chem. 2019;62(17):7923–40. https://doi.org/10.1021/acs.jmedchem.9b00687.
Article CAS PubMed Google Scholar
Brown JR, Eichhorst B, Hillmen P, Jurczak W, Kaźmierczak M, Lamanna N, et al. Zanubrutinib or ibrutinib in relapsed or refractory chronic lymphocytic leukemia. N Engl J Med. 2023;388(4):319–32. https://doi.org/10.1056/NEJMoa2211582.
Article CAS PubMed Google Scholar
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, et al. NCCN Guidelines® insights: chronic lymphocytic leukemia/small lymphocytic lymphoma, Version 3.2022. J Natl Compr Canc Netw. 2022;20(6):622–34. https://doi.org/10.6004/jnccn.2022.0031.
Article CAS PubMed Google Scholar
Eichhorst B, Robak T, Montserrat E, Ghia P, Niemann CU, Kater AP, et al. Chronic lymphocytic leukaemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021;32(1):23–33. https://doi.org/10.1016/j.annonc.2020.09.019.
Article CAS PubMed Google Scholar
Chen Q, Jain N, Ayer T, Wierda WG, Flowers CR, et al. Economic burden of chronic lymphocytic leukemia in the era of oral targeted therapies in the United States. J Clin Oncol. 2017;35(2):166–74. https://doi.org/10.1200/JCO.2016.68.2856.
Article CAS PubMed Google Scholar
Mato AR, Thompson M, Allan JN, Brander DM, Pagel JM, Ujjani CS, et al. Real-world outcomes and management strategies for venetoclax-treated chronic lymphocytic leukemia patients in the United States. Haematologica. 2018;103(9):1511–7. https://doi.org/10.3324/haematol.2018.193615.
Article CAS PubMed PubMed Central Google Scholar
Winqvist M, Asklid A, Andersson PO, Karlsson K, Karlsson C, Lauri B, et al. Real-world results of ibrutinib in patients with relapsed or refractory chronic lymphocytic leukemia: data from 95 consecutive patients treated in a compassionate use program: a study from the Swedish Chronic Lymphocytic Leukemia Group. Haematologica. 2016;101(12):1573–80. https://doi.org/10.3324/haematol.2016.144576.
Article CAS PubMed PubMed Central Google Scholar
Abrisqueta P, Loscertales J, Terol MJ, Ramírez Payer Á, Ortiz M, Pérez I, et al. Real-world characteristics and outcome of patients treated with single-agent ibrutinib for chronic lymphocytic leukemia in Spain (IBRORS-LLC Study). Clin Lymphoma Myeloma Leuk. 2021;21(12):e985–99. https://doi.org/10.1016/j.clml.2021.07.022.
Article CAS PubMed Google Scholar
UK Cll Forum. Ibrutinib for relapsed/refractory chronic lymphocytic leukemia: a UK and Ireland analysis of outcomes in 315 patients. Haematologica. 2016;101(12):1563–72. https://doi.org/10.3324/haematol.2016.147900.
Article CAS PubMed Central Google Scholar
Haacker M, Hallett TB, Atun R. On discount rates for economic evaluations in global health. Health Policy Plan. 2020;35(1):107–14. https://doi.org/10.1093/heapol/czz127.
Latimer N. NICE DSU technical support document 14: survival analysis for economic evaluations alongside clinical trials: extrapolation with patient-level data. 2011. https://www.ncbi.nlm.nih.gov/books/NBK395885/pdf/Bookshelf_NBK395885.pdf. Accessed 13 Aug 2023.
Mitchell M. Engauge digitizer software. http://markummitchell.github.io/engauge-digitizer. Accessed 28 Dec 2023.
Guyot P, Ades AE, Ouwens MJ, Welton NJ. Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves. BMC Med Res Methodol. 2012;12:9. https://doi.org/10.1186/1471-2288-12-9.
Article PubMed PubMed Central Google Scholar
R Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/. Accessed 28 Dec 2023.
Social Security. Actuarial life table. https://www.ssa.gov/oact/STATS/table4c6.html. Accessed 23 Aug 2023.
Lexicomp. https://www.wolterskluwer.com/en/solutions/lexicomp/lexicomp. Accessed 23 Apr 2023.
Alrawashdh N, McBride A, Erstad B, Sweasy J, Persky DO, Abraham I. Cost-effectiveness and economic burden analyses on all first-line treatments of chronic lymphocytic leukemia. Value Health. 2022;25(10):1685–95. https://doi.org/10.1016/j.jval.2022.04.001.
Reyes C, Engel-Nitz NM, DaCosta BS, Ravelo A, Ogale S, Bancroft T, et al. Cost of disease progression in patients with chronic lymphocytic leukemia, acute myeloid leukemia, and non-Hodgkin’s lymphoma. Oncologist. 2019;24(9):1219–28. https://doi.org/10.1634/theoncologist.2018-0019.
Article PubMed PubMed Central Google Scholar
Munir T, Genovez V, Genestier V, Ryan K, Liljas B, Gaitonde P. Cost-effectiveness of acalabrutinib regimens in treatment-naïve chronic lymphocytic leukemia in the United States. Expert Rev Pharmacoecon Outcomes Res. 2023;23(5):579–89. https://doi.org/10.1080/14737167.2023.2196408.
National Cancer Institute. Financial burden of cancer care. https://progressreport.cancer.gov/after/economic_burden. Accessed 25 Aug 2023.
Federal Reserve Economic Data. Consumer price index for all urban consumers: medical care in U.S. City average. https://fred.stlouisfed.org/series/CPIMEDSL. Accessed 23 Aug 2023.
National Institute for Health and Care Excellence. Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia. 2019. http://www.nice.org.uk/guidance/ta561. Accessed 29 Nov 2023.
Patel KK, Isufi I, Kothari S, Davidoff AJ, Gross CP, Huntington SF. Cost-effectiveness of first-line vs third-line ibrutinib in patients with untreated chronic lymphocytic leukemia. Blood. 2020;136(17):1946–55. https://doi.org/10.1182/blood.2020004922.
Barnes JI, Divi V, Begaye A, Wong R, Coutre S, Owens DK, et al. Cost-effectiveness of ibrutinib as first-line therapy for chronic lymphocytic leukemia in older adults without deletion 17p. Blood Adv. 2018;2(15):1946–56. https://doi.org/10.1182/bloodadvances.2017015461.
Article CAS PubMed PubMed Central Google Scholar
Neumann PJ, Kim DD. Cost-effectiveness thresholds used by study authors, 1990–2021. JAMA. 2023;329(15):1312–4. https://doi.org/10.1001/jama.2023.1792.
Article PubMed PubMed Central Google Scholar
Hatswell AJ, Bullement A, Briggs A, Paulden M, Stevenson MD. Probabilistic sensitivity analysis in cost-effectiveness models: determining model convergence in cohort models. Pharmacoeconomics. 2018;36(12):1421–6. https://doi.org/10.1007/s40273-018-0697-3.
National Cancer Institute. Cancer Stat Facts: leukemia: chronic lymphocytic leukemia (CLL). https://seer.cancer.gov/statfacts/html/clyl.html. Accessed 28 Nov 2023.
Barbier M, Durno N, Bennison C, Örtli M, Knapp C, Schwenkglenks M. Cost-effectiveness and budget impact of venetoclax in combination with rituximab in relapsed/refractory chronic lymphocytic leukemia in Switzerland. Eur J Health Econ. 2022;23(5):837–46. https://doi.org/10.1007/s10198-021-01398-7.
Vemer P, Corro RI, van Voorn GA, Al MJ, Feenstra TL. AdViSHE: a validation-assessment tool of health-economic models for decision makers and model users. Pharmacoeconomics. 2016;34(4):349–61. https://doi.org/10.1007/s40273-015-0327-2.
Article CAS PubMed Google Scholar
Vreman RA, Geenen JW, Hövels AM, Goettsch WG, Leufkens HGM, Al MJ. Phase I/II clinical trial-based early economic evaluation of acalabrutinib for relapsed chronic lymphocytic leukaemia. Appl Health Econ Health Policy. 2019;17(6):883–93. https://doi.org/10.1007/s40258-019-00496-1.
Article PubMed PubMed Central Google Scholar
Cull G, Burger JA, Opat S, Gottlieb D, Verner E, Trotman J, et al. Zanubrutinib for treatment-naïve and relapsed/refractory chronic lymphocytic leukaemia: long-term follow-up of the phase I/II AU-003 study. Br J Haematol. 2022;196(5):1209–18. https://doi.org/10.1111/bjh.17994.
Article CAS PubMed Google Scholar
Byrd JC, Brown JR, O’Brien S, Barrientos JC, Kay NE, Reddy NM, et al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N Engl J Med. 2014;371(3):213–23. https://doi.org/10.1056/NEJMoa1400376.
Article CAS PubMed PubMed Central Google Scholar
Woyach JA, Ruppert AS, Heerema NA, Zhao W, Booth AM, Ding W, et al. Ibrutinib regimens versus chemoimmunotherapy in older patients with untreated CLL. N Engl J Med. 2018;379(26):2517–28. https://doi.org/10.1056/NEJMoa1812836.
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