CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J Clin. 2021;71(3):209–49.

Article  Google Scholar 

Abu-Rustum NR, Yashar CM, Bean S, Bradley K, Campos SM, Chon HS, et al. NCCN guidelines insights: cervical cancer, version 1.2020. J Natl Compr Cancer Network: JNCCN. 2020;18(6):660–6.

Article  PubMed  Google Scholar 

Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R. Cancer of the cervix uteri. Int J Gynaecol Obstet. 2018;143(Suppl 2):22–36.

Article  PubMed  Google Scholar 

Li J, Sun D, Pu W, Wang J, Peng Y. Circular RNAs in cancer: biogenesis, function, and clinical significance. Trends Cancer. 2020;6(4):319–36.

Article  CAS  PubMed  Google Scholar 

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495(7441):333–8.

Article  CAS  PubMed  ADS  Google Scholar 

Vo JN, Cieslik M, Zhang Y, Shukla S, Xiao L, Zhang Y, et al. The Landscape of Circular RNA in Cancer. Cell. 2019;176(4):869–81e13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang F, Hu A, Li D, Wang J, Guo Y, Liu Y, et al. Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation. Mol Cancer. 2019;18(1):158.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng W, Wang X, Yu Y, Ji C, Fang L. CircRNF10-DHX15 interaction suppressed breast cancer progression by antagonizing DHX15-NF-κB p65 positive feedback loop. Cell Mol Biol Lett. 2023;28(1):34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du J, Zhang G, Qiu H, Yu H, Yuan W. The novel circular RNA circ-CAMK2A enhances lung adenocarcinoma metastasis by regulating the miR-615-5p/fibronectin 1 pathway. Cell Mol Biol Lett. 2019;24:72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu T, Cen Y, Chen Z, Zhang Y, Zhao L, Wang J, et al. Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer. Cell Death Dis. 2022;13(5):479.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang C, Liu P, Huang J, Liao Y, Pan C, Liu J, et al. Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis. Cell Death Dis. 2021;12(10):888.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Chen T, Li C, Li W, Zhou X, Li Y, et al. CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR. J Hematol Oncol. 2022;15(1):122.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yi J, Wang L, Hu GS, Zhang YY, Du J, Ding JC, et al. CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS. EMBO J. 2023;42(10):e112408.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang C, Jiang H, Yuan L, Liao Y, Liu P, Du Q, et al. CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability. Oncogene. 2023;42(11):793–807.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He PC, He C. m(6) A RNA methylation: from mechanisms to therapeutic potential. EMBO J. 2021;40(3):e105977.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roundtree IA, Evans ME, Pan T, He C. Dynamic RNA modifications in gene expression regulation. Cell. 2017;169(7):1187–200.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du D, He J, Ju C, Wang C, Li H, He F, et al. When N(7)-methyladenosine modification meets cancer: Emerging frontiers and promising therapeutic opportunities. Cancer Lett. 2023;562:216165.

Article  CAS  PubMed  Google Scholar 

Liu K, Xu P, Lv J, Ge H, Yan Z, Huang S, et al. Peritoneal high-fat environment promotes peritoneal metastasis of gastric cancer cells through activation of NSUN2-mediated ORAI2 m5C modification. Oncogene. 2023;42(24):1980–93.

Article  CAS  PubMed  Google Scholar 

Arango D, Sturgill D, Alhusaini N, Dillman AA, Sweet TJ, Hanson G, et al. Acetylation of Cytidine in mRNA Promotes Translation Efficiency. Cell. 2018;175(7):1872–86e24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma S, Langhendries JL, Watzinger P, Kötter P, Entian KD, Lafontaine DL. Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1. Nucleic Acids Res. 2015;43(4):2242–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ito S, Horikawa S, Suzuki T, Kawauchi H, Tanaka Y, Suzuki T, et al. Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA). J Biol Chem. 2014;289(52):35724–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng X, Wang Q, Zhou Y, Zhang D, Geng Y, Hu W, et al. N-acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4-acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA. Cancer Commun. 2022;42(12):1347–66.

Article  Google Scholar 

Feng Z, Li K, Qin K, Liang J, Shi M, Ma Y, et al. The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA. J Hematol Oncol. 2022;15(1):112.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang C, Liao Y, Liu P, Du Q, Liang Y, Ooi S, et al. FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism. Theranostics. 2020;10(15):6561–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao Y, Huang J, Liu P, Zhang C, Liu J, Xia M, et al. Downregulation of LNMAS orchestrates partial EMT and immune escape from macrophage phagocytosis to promote lymph node metastasis of cervical cancer. Oncogene. 2022;41(13):1931–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Q, Wang H, Li Z, Li F, Liang L, Zou Y, et al. Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription. J Hepatol. 2022;76(1):135–47.

Article  CAS  PubMed  Google Scholar 

Pan X, Huang B, Ma Q, Ren J, Liu Y, Wang C, et al. Circular RNA circ-TNPO3 inhibits clear cell renal cell carcinoma metastasis by binding to IGF2BP2 and destabilizing SERPINH1 mRNA. Clin translational Med. 2022;12(7):e994.

Article  CAS  Google Scholar 

Lee CK, Jeong SH, Jang C, Bae H, Kim YH, Park I, et al. Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation. Science. 2019;363(6427):644–9.

Article  CAS  PubMed  ADS  Google Scholar 

Liu J, Bai W, Zhou T, Xie Y, Yang B, Sun J, et al. SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation. Gut. 2023;72(9):1722–37.

Article  CAS  PubMed  Google Scholar 

Deng M, Zhang L, Zheng W, Chen J, Du N, Li M, et al. Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression. J Exp Clin Cancer Res. 2023;42(1):9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng Y, Pan D. The hippo signaling pathway in development and disease. Dev Cell. 2019;50(3):264–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miao D, Wang Q, Shi J, Lv Q, Tan D, Zhao C, et al. N6-methyladenosine-modified DBT alleviates lipid accumulation and inhibits tumor progression in clear cell renal cell carcinoma through the ANXA2/YAP axis-regulated Hippo pathway. Cancer Commun. 2023;43(4):480–502.

Article  Google Scholar 

Wang D, He J, Dong J, Wu S, Liu S, Zhu H, et al. UM-6 induces autophagy and apoptosis via the Hippo-YAP signaling pathway in cervical cancer. Cancer Lett. 2021;519:2–19.

Article  CAS  PubMed  Google Scholar 

He C, Mao D, Hua G, Lv X, Chen X, Angeletti PC, et al. The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression. EMBO Mol Med. 2015;7(11):1426–49.

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif