Potential drug candidates against Hepatitis C virus: In silico screening of phytoconstituents from Phyllanthus fraternus G.L. Webster
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https://doi.org/10.56042/ijeb.v62i01.4628Title: Potential drug candidates against Hepatitis C virus: In silico screening of phytoconstituents from Phyllanthus fraternus G.L. WebsterAuthors:
Upadhyay, RichaTiwari, Kavindra NathKeywords: Blood brain absorption;CaCo2 permeability;Gulf leaf-flower;Human intestinal absorption;LiverIssue Date: Dec-2023Publisher: NIScPR-CSIR,IndiaAbstract: Hepatitis C is a liver inflammatory disease caused by the Hepatitis C virus. Phyllanthus fraternus G.L. Webster,
commonly called Gulf leaf-flower, is an important medicinal plant and possesses hepatoprotective activity against hepatitis.
Here, we have determined and characterized the active ingredients from the leaf extract of P. fraternus by gas
chromatography-mass spectrometry (GC-MS) analysis. It resulted in the identification of fifteen compounds, which are the
first to be reported from P. fraternus. For finding the compounds responsible for HCV, identified compounds were docked
against important enzymes of HCV virus metabolism viz; HCVNS3 enzyme, HCVNS5, and hepatic damage indicator
enzymes AST and ALT. To ensure drug-likeness, the pharmacokinetic, physiochemical, and toxicity properties of the
compounds were also evaluated. The study has demonostrated the presence of seven hepatoprotective compounds alphacadinol,
elemol, 1,6-germacradien-5-ol, phytol, carissanol dimethyl ether, phyltetralin and 3-furanmethanol, alpha-(3,4-
dimethoxyphenyl) tetrahydro-3-hydroxy-4-veratryl- in the leaves extract of P. fraternus against the hepatitis C virus.Page(s): 17-27ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:
IJEB Vol.62(01) [Jan 2024]Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.
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