ROS production by mitochondria: function or dysfunction?

Fabian M, Wong WW, Gennis RB, Palmer G. Mass spectrometric determination of dioxygen bond splitting in the “peroxy” intermediate of cytochrome c oxidase. Proc Natl Acad Sci USA. 1999;96:13114–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babcock GT. How oxygen is activated and reduced in respiration. Proc Natl Acad Sci USA. 1999;96:12971–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev. 1979;59:527–605.

Article  CAS  PubMed  Google Scholar 

Jain M, Rivera S, Monclus EA, Synenki L, Zirk A, Eisenbart J, et al. Mitochondrial reactive oxygen species regulate transforming growth factor-beta signaling. J Biol Chem. 2013;288:770–7.

Article  CAS  PubMed  Google Scholar 

Bell EL, Klimova TA, Eisenbart J, Moraes CT, Murphy MP, Budinger GR, et al. The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol. 2007;177:1029–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stepanova A, Konrad C, Manfredi G, Springett R, Ten V, Galkin A. The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A. J Neurochem. 2019;148:731–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roca FJ, Whitworth LJ, Prag HA, Murphy MP, Ramakrishnan L. Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport. Science. 2022;376:eabh2841.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grivennikova VG, Kareyeva AV, Vinogradov AD. Oxygen-dependence of mitochondrial ROS production as detected by Amplex Red assay. Redox Biol. 2018;17:192–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scialo F, Sanz A. Coenzyme Q redox signalling and longevity. Free Radic Biol Med. 2021;164:187–205.

Article  CAS  PubMed  Google Scholar 

Herrero D, Tome M, Canon S, Cruz FM, Carmona RM, Fuster E, et al. Redox-dependent BMI1 activity drives in vivo adult cardiac progenitor cell differentiation. Cell Death Differ. 2018;25:809–22.

Article  CAS  PubMed  Google Scholar 

Chouchani ET, Kazak L, Spiegelman BM. Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms. J Biol Chem. 2017;292:16810–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA. 1998;95:11715–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem. 2000;275:25130–8.

Article  CAS  PubMed  Google Scholar 

Bastin J, Sroussi M, Nemazanyy I, Laurent-Puig P, Mouillet-Richard S, Djouadi F. Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration. J Transl Med. 2023;21:522.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han L, Zhang C, Wang D, Zhang J, Tang Q, Li MJ, et al. Retrograde regulation of mitochondrial fission and epithelial to mesenchymal transition in hepatocellular carcinoma by GCN5L1. Oncogene. 2023;42:1024–37.

Article  CAS  PubMed  Google Scholar 

Kinugasa H, Whelan KA, Tanaka K, Natsuizaka M, Long A, Guo A, et al. Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression. Oncogene. 2015;34:5229–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bazopoulou D, Knoefler D, Zheng Y, Ulrich K, Oleson BJ, Xie L, et al. Developmental ROS individualizes organismal stress resistance and lifespan. Nature. 2019;576:301–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palma FR, Ogata FT, Coelho DR, Pulakanti K, Meyer A, Huang Y et al. H3.1Cys96 oxidation by mitochondrial ROS promotes chromatin remodeling, breast cancer progression to metastasis and multi-drug resistance. bioRxiv (2022). 2022.2012.2001.517361.

Baek Y, Woo TG, Ahn J, Lee D, Kwon Y, Park BJ, et al. Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation. Commun Biol. 2022;5:1085.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paviani V, Junqueira de Melo P, Avakin A, Di Mascio P, Ronsein GE, Augusto O. Human cataractous lenses contain cross-links produced by crystallin-derived tryptophanyl and tyrosyl radicals. Free Radic Biol Med. 2020;160:356–67.

Article  CAS  PubMed  Google Scholar 

Godoy LC, Munoz-Pinedo C, Castro L, Cardaci S, Schonhoff CM, King M, et al. Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells. Proc Natl Acad Sci USA. 2009;106:2653–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, Bartholomew PJ, et al. Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem. 2005;280:16916–24.

Article  CAS  PubMed  Google Scholar 

Bonini MG, Siraki AG, Atanassov BS, Mason RP. Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes. Free Radic Biol Med. 2007;42:530–40.

Article  CAS  PubMed  Google Scholar 

Rocco-Machado N, Lai L, Kim G, He Y, Luczak ED, Anderson ME, et al. Oxidative stress-induced autonomous activation of the calcium/calmodulin-dependent kinase II involves disulfide formation in the regulatory domain. J Biol Chem. 2022;298:102579.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rass U, Ahel I, West SC. Defective DNA repair and neurodegenerative disease. Cell. 2007;130:991–1004.

Article  CAS  PubMed  Google Scholar 

Horwitz E, Krogvold L, Zhitomirsky S, Swisa A, Fischman M, Lax T, et al. beta-cell DNA damage response promotes islet inflammation in type 1diabetes. Diabetes. 2018;67:2305–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aydin E, Hallner A, Grauers Wiktorin H, Staffas A, Hellstrand K, Martner A. NOX2 inhibition reduces oxidative stress and prolongs survival in murine KRAS-induced myeloproliferative disease. Oncogene. 2019;38:1534–43.

Article  CAS  PubMed  Google Scholar 

Schroyer AL, Stimes NW, Abi Saab WF, Chadee DN. MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells. Oncogene. 2018;37:1031–40.

Article  CAS  PubMed  Google Scholar 

Mangerich A, Knutson CG, Parry NM, Muthupalani S, Ye W, Prestwich E, et al. Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. Proc Natl Acad Sci USA. 2012;109:E1820–9.

Article  PubMed  PubMed Central  Google Scholar 

McBride TJ, Schneider JE, Floyd RA, Loeb LA. Mutations induced by methylene blue plus light in single-stranded M13mp2. Proc Natl Acad Sci USA. 1992;89:6866–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Michaels ML, Cruz C, Grollman AP, Miller JH. Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc Natl Acad Sci USA. 1992;89:7022–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsuzuki T, Egashira A, Igarashi H, Iwakuma T, Nakatsuru Y, Tominaga Y, et al. Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Proc Natl Acad Sci USA. 2001;98:11456–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hyun JW, Choi JY, Zeng HH, Lee YS, Kim HS, Yoon SH, et al. Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1. Oncogene. 2000;19:4476–9.

Article  CAS  PubMed  Google Scholar 

Trinei M, Giorgio M, Cicalese A, Barozzi S, Ventura A, Migliaccio E, et al. A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene. 2002;21:3872–8.

Article  CAS  PubMed 

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