Jin MZ, Jin WL. The updated landscape of tumor microenvironment and drug repurposing. Signal Transduct Target Ther. 2020;5:166.

Article  PubMed  PubMed Central  Google Scholar 

Zhao CM, Hayakawa Y, Kodama Y, Muthupalani S, Westphalen CB, Andersen GT, et al. Denervation suppresses gastric tumorigenesis. Sci Transl Med. 2014;6:250ra115.

Article  PubMed  PubMed Central  Google Scholar 

Rabben HL, Zhao CM, Hayakawa Y, Wang TC, Chen D. Vagotomy and gastric tumorigenesis. Curr Neuropharmacol. 2016;14:967–72.

Article  PubMed  PubMed Central  Google Scholar 

Tong Y, Gao HR, Qi QC, Liu XY, Li J, Gao J, et al. High fat diet, gut microbiome, and gastrointestinal cancer. Theranostics. 2021;11:5889–910.

Article  PubMed  PubMed Central  Google Scholar 

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. Ca-Cancer J Clin. 2023;73:17–48.

Article  PubMed  Google Scholar 

Feng RM, Su QL, Huang XY, Basnet T, Xu X, Ye WM. Cancer situation in China: what does the China cancer map indicate from the first national death survey to the latest cancer registration? Cancer Commun. 2023;43:75–86.

Article  Google Scholar 

Takayama S, Takahashi H, Matsuo Y, Okada Y, Manabe T. Effects of Helicobacter pylori infection on human pancreatic cancer cell line. Hepatogastroenterology. 2007;54:2387–91.

PubMed  Google Scholar 

Wells JE, Hylemon PB. Identification and characterization of a bile acid 7-alpha-dehydroxylation operon in Clostridium sp. strain TO-931, a highly active 7-alpha-dehydroxylating strain isolated from human feces. Appl Environ Microbiol. 2000;66:1107–13.

Article  PubMed  PubMed Central  Google Scholar 

Wood LD, Canto MI, Jaffee EM, Simeone DM. Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment. Gastroenterology. 2022;163:386–402.

Article  PubMed  Google Scholar 

Aqel B, DiBaise JK. Role of the gut microbiome in nonalcoholic fatty liver disease. Nutr Clin Pr. 2015;30:780–6.

Article  Google Scholar 

Gerbe F, van Es JH, Makrini L, Brulin B, Mellitzer G, Robine S, et al. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol. 2011;192:767–80.

Article  PubMed  PubMed Central  Google Scholar 

Rao M, Gershon MD. The bowel and beyond: the enteric nervous system in neurological disorders. Nat Rev Gastroenterol Hepatol. 2016;13:517–28.

Article  PubMed  PubMed Central  Google Scholar 

Birder L, de Groat W, Mills I, Morrison J, Thor K, Drake M. Neural control of the lower urinary tract: peripheral and spinal mechanisms. Neurourol Urodyn. 2010;29:128–39.

Article  PubMed  PubMed Central  Google Scholar 

Sternini C. Organization of the peripheral nervous system: autonomic and sensory ganglia. J Investig Dermatol Symp Proc. 1997;2:1–7.

Article  PubMed  Google Scholar 

Wehrwein EA, Orer HS, Barman SM. Overview of the anatomy, physiology, and pharmacology of the autonomic nervous system. Compr Physiol. 2016;6:1239–78.

Article  PubMed  Google Scholar 

Spencer NJ, Hu H. Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility. Nat Rev Gastroenterol Hepatol. 2020;17:338–51.

Article  PubMed  PubMed Central  Google Scholar 

Holland AM, Bon-Frauches AC, Keszthelyi D, Melotte V, Boesmans W. The enteric nervous system in gastrointestinal disease etiology. Cell Mol Life Sci. 2021;78:4713–33.

Article  PubMed  PubMed Central  Google Scholar 

Furness JB, Kunze WA, Bertrand PP, Clerc N, Bornstein JC. Intrinsic primary afferent neurons of the intestine. Prog Neurobiol. 1998;54:1–18.

Article  PubMed  Google Scholar 

Forsythe P, Bienenstock J, Kunze WA. Vagal pathways for microbiome-brain-gut axis communication. Adv Exp Med Biol. 2014;817:115–33.

Article  PubMed  Google Scholar 

Schutz B, Jurastow I, Bader S, Ringer C, von Engelhardt J, Chubanov V, et al. Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract. Front Physiol. 2015;6:87.

PubMed  PubMed Central  Google Scholar 

Gerbe F, Jay P. Intestinal tuft cells: epithelial sentinels linking luminal cues to the immune system. Mucosal Immunol. 2016;9:1353–9.

Article  PubMed  Google Scholar 

McLean L, Smith A, Cheung LM, Desai N, Grinchuk V, Zhao AP, et al. Type 3 muscarinic receptors (M3R) contribute to expulsion of Nippostrongylus brasiliensis through induction of Th2 cytokines. Am J Gastroenterol. 2014;109:S502.

Article  Google Scholar 

Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, McDonald PG, et al. Opinion—The influence of bio-behavioral factors on tumor biology: pathways and mechanisms. Nat Rev Cancer. 2006;6:240–8.

Article  PubMed  PubMed Central  Google Scholar 

Yang TT, Qiao Y, Xiang SY, Li WZ, Gan Y, Chen YC. Work stress and the risk of cancer: a meta-analysis of observational studies. Int J Cancer. 2019;144:2390–400.

Article  PubMed  Google Scholar 

Cao L, Liu X, Lin EJ, Wang C, Choi EY, Riban V, et al. Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition. Cell. 2010;142:52–64.

Article  PubMed  PubMed Central  Google Scholar 

Cheng XJ, Lin JC, Tu SP. Etiology and prevention of gastric cancer. Gastrointest tumors. 2016;3:25–36.

Article  PubMed  PubMed Central  Google Scholar 

Neumann ID, Landgraf R. Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors. Trends Neurosci. 2012;35:649–59.

Article  PubMed  Google Scholar 

Pan S, Yin K, Tang Z, Wang S, Chen Z, Wang Y, et al. Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice. Elife. 2021;10:e67535.

Article  PubMed  PubMed Central  Google Scholar 

Ganguly S, Basu B, Shome S, Jadhav T, Roy S, Majumdar J, et al. Dopamine, by acting through Its D-2 receptor, inhibits insulin-like growth factor-I (IGF-I)-induced gastric cancer cell proliferation via up-regulation of kruppel-like factor 4 through down-regulation of IGF-IR and AKT phosphorylation. Am J Pathol. 2010;177:2701–7.

Article  PubMed  PubMed Central  Google Scholar 

Lee H, Shim S, Kong JS, Kim MJ, Park S, Lee SS, et al. Overexpression of dopamine receptor D2 promotes colorectal cancer progression by activating the beta-catenin/ZEB1 axis. Cancer Sci. 2021;112:3732–43.

Article  PubMed  PubMed Central  Google Scholar 

Mazzone SB, Undem BJ. Vagal afferent innervation of the airways in health and disease. Physiol Rev. 2016;96:975–1024.

Article  PubMed  PubMed Central  Google Scholar 

Nilius B, Owsianik G. The transient receptor potential family of ion channels. Genome Biol. 2011;12:218.

Article  PubMed  PubMed Central  Google Scholar 

Johnson MB, Young AD, Marriott I. The therapeutic potential of targeting substance P/NK-1R interactions in inflammatory CNS disorders. Front Cell Neurosci. 2016;10:296.

PubMed  Google Scholar 

Liu H, Li X, Xu Q, Lv S, Li J, Ma Q. Role of glial cell line-derived neurotrophic factor in perineural invasion of pancreatic cancer. Biochim Biophys Acta. 2012;1826:112–20.

PubMed  Google Scholar 

Toda K, Nagasaka T, Umeda Y, Tanaka T, Kawai T, Fuji T, et al. Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability. Clin Epigenetics. 2015;7:73.

Article  PubMed  PubMed Central  Google Scholar 

Shin SK, Nagasaka T, Jung BH, Matsubara N, Kim WH, Carethers JM, et al. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology. 2007;133:1849–57.

Article  PubMed  Google Scholar 

Yin K, Shang M, Dang S, Wang L, Xia Y, Cui L, et al. Netrin‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation. Oncol Rep. 2018;40:2325–33.

PubMed  Google Scholar 

Yin K, Dang S, Cui L, Fan X, Wang L, Xie R, et al. Netrin-1 promotes metastasis of gastric cancer by regulating YAP activity. Biochem Biophys Res Commun. 2018;496:76–82.

Article  PubMed  Google Scholar 

Yin K, Wang LJ, Zhang X, He ZY, Xia YW, Xu JH, et al. Netrin-1 promotes gastric cancer cell proliferation and invasion via the receptor neogenin through PI3K/AKT signaling pathway. Oncotarget. 2017;8:51177–89.

Article  PubMed  PubMed Central  Google Scholar 

Yan W, Han P, Zhou ZZ, Tu W, Liao JZ, Li PY, et al. Netrin-1 induces epithelial-mesenchymal transition and promotes hepatocellular carcinoma invasiveness. Dig Dis Sci. 2014;59:1213–21.

Article  PubMed  Google Scholar 

Fang X, Xu Y, Li K, Liu P, Zhang H, Jiang Y, et al. Exosomal lncRNA PCAT1 promotes tumor-circulating cell-mediated colorectal cancer liver metastasis by regulating the activity of the miR-329-3p/Netrin-1-CD146 complex. J Immunol Res. 2022;2022:9916228.