These authors contributed equally: Xiaoyu Song, Fengrui Yang, Tongtong Yang, Yong Wang, Mingrui Ding, Linge Li.

These authors jointly supervised this work: Xing Liu, Xuebiao Yao.

MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Center for Cross-disciplinary Sciences, University of Science & Technology of China School of Life Sciences, Hefei, China

Xiaoyu Song, Fengrui Yang, Tongtong Yang, Mingrui Ding, Panpan Xu, Shuaiyu Liu, Ming Dai, Changbiao Chi, Shengqi Xiang, Chao Xu, Zhikai Wang, Chuanhai Fu, Jianye Zang, Yunyu Shi, Xing Liu & Xuebiao Yao

Keck Center for Organoids Plasticity, Morehouse School of Medicine, Atlanta, GA, USA

Xiaoyu Song, Fengrui Yang, Mingrui Ding, Zhikai Wang & Xing Liu

Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China

Yong Wang & Kai Jiang

Anhui Key Laboratory for Chemical Biology & Hefei National Center for Cross-disciplinary Sciences, Hefei, China

Linge Li, Shuaiyu Liu & Zhonghuai Hou

Institute of Biophysics, Beijing, China

Dong Li

CAS Center of Excellence in Molecular Cell Sciences, Chinese Academy of Sciences, Shanghai, China

Lin Li

Department of Pathology, University of Alabama, Birmingham, AL, USA

Donald L. Hill

Hunan Key Laboratory of Molecular Precision Medicine, Central South University School of Life Sciences, Changsha, China

Kai Yuan

School of Life Sciences, Tsinghua University, Beijing, China

Pilong Li