Armstrong MAL. A Type-I interferon responses: from friend to foe in the battle against chronic viral infection. Front Immunol. 2016;7:609.

Google Scholar 

Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol. 2005;5(5):375–86. https://doi.org/10.1038/nri1604.

Article  PubMed  CAS  Google Scholar 

Mesev EV, LeDesma RA, Ploss A. Decoding type I and III interferon signalling during viral infection. Nat Microbiol. 2019;4(6):914–24. https://doi.org/10.1038/s41564-019-0421-x.

Article  PubMed  PubMed Central  CAS  Google Scholar 

•• Cooles FA, Isaacs JD. The interferon gene signature as a clinically relevant biomarker in autoimmune rheumatic disease. Lancet Rheumatol. 2021;4(1) https://doi.org/10.1016/S2665-9913(21)00254-X. A recent review exploring how a raised IGS can function as a clinically relevant biomarker in rheumatic diseases.

•• Rodriguez-Carrio J, Burska A, Conaghan PG, Dik WA, Biesen R, Eloranta ML, et al. EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice. Ann Rheum Dis. 2023;82(6):754–62. https://doi.org/10.1136/ard-2022-223628. A thorough review of using IFN-I assays in clinical research and their clinical utility.

Reynier F, Petit F, Paye M, Turrel-Davin F, Imbert PE, Hot A, et al. Importance of correlation between gene expression levels: application to the type I interferon signature in rheumatoid arthritis. PLoS One. 2011;6(10):e24828. https://doi.org/10.1371/journal.pone.0024828.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Smiljanovic B, Grun JR, Biesen R, Schulte-Wrede U, Baumgrass R, Stuhlmuller B, et al. The multifaceted balance of TNF-alpha and type I/II interferon responses in SLE and RA: how monocytes manage the impact of cytokines. J Mol Med (Berl). 2012;90(11):1295–309. https://doi.org/10.1007/s00109-012-0907-y.

Article  PubMed  CAS  Google Scholar 

Nzeusseu Toukap A, Galant C, Theate I, Maudoux AL, Lories RJ, Houssiau FA, et al. Identification of distinct gene expression profiles in the synovium of patients with systemic lupus erythematosus. Arthritis Rheum. 2007;56(5):1579–88. https://doi.org/10.1002/art.22578.

Article  PubMed  CAS  Google Scholar 

de Jong TD, Vosslamber S, Mantel E, de Ridder S, Wesseling JG, van der Pouw Kraan TC, et al. Physiological evidence for diversification of IFNalpha- and IFNbeta-mediated response programs in different autoimmune diseases. Arthritis Res Ther. 2016;18:49. https://doi.org/10.1186/s13075-016-0946-9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

van Boxel-Dezaire AH, Zula JA, Xu Y, Ransohoff RM, Jacobberger JW, Stark GR. Major differences in the responses of primary human leukocyte subsets to IFN-beta. J Immunol. 2010;185(10):5888–99. https://doi.org/10.4049/jimmunol.0902314.

Article  PubMed  Google Scholar 

Henig N, Avidan N, Mandel I, Staun-Ram E, Ginzburg E, Paperna T, et al. Interferon-beta induces distinct gene expression response patterns in human monocytes versus T cells. PLoS One. 2013;8(4):e62366. https://doi.org/10.1371/journal.pone.0062366.

Article  PubMed  PubMed Central  CAS  Google Scholar 

•• FAH C, Tarn J, Lendrem DW, Naamane N, Lin CM, Millar B, et al. Interferon-alpha-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming. Ann Rheum Dis. 2022;81(9):1214–23. https://doi.org/10.1136/annrheumdis-2022-222370. This study used a multicentre inception cohort of early RA patients to demonstrate the IGS as a robust prognostic biomarker for early RA, specifically with regards to the IGS as a reflection of circulating IFN-α protein and influencer of epigenome.

Cooles FAH, Anderson AE, Lendrem DW, Norris J, Pratt AG, Hilkens CMU, et al. The interferon gene signature is increased in patients with early treatment-naive rheumatoid arthritis and predicts a poorer response to initial therapy. J Allergy Clin Immunol. 2018;141(1):445–8 e4. https://doi.org/10.1016/j.jaci.2017.08.026.

Article  PubMed  PubMed Central  CAS  Google Scholar 

de Jong TD, Sellam J, Agca R, Vosslamber S, Witte BI, Tsang ASM, et al. A multi-parameter response prediction model for rituximab in rheumatoid arthritis. Joint Bone Spine. 2018;85(2):219–26. https://doi.org/10.1016/j.jbspin.2017.02.015.

Article  PubMed  CAS  Google Scholar 

Rodriguez-Carrio J, Alperi-Lopez M, Lopez P, Ballina-Garcia FJ, Suarez A. Heterogeneity of the type I interferon signature in rheumatoid arthritis: a potential limitation for its use as a clinical biomarker. Front Immunol. 2017;8:2007. https://doi.org/10.3389/fimmu.2017.02007.

Article  PubMed  CAS  Google Scholar 

Seyhan AA, Gregory B, Cribbs AP, Bhalara S, Li Y, Loreth C, et al. Novel biomarkers of a peripheral blood interferon signature associated with drug-naive early arthritis patients distinguish persistent from self-limiting disease course. Sci Rep. 2020;10(1):8830. https://doi.org/10.1038/s41598-020-63757-3.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lubbers J, Brink M, van de Stadt LA, Vosslamber S, Wesseling JG, van Schaardenburg D, et al. The type I IFN signature as a biomarker of preclinical rheumatoid arthritis. Ann Rheum Dis. 2013;72(5):776–80. https://doi.org/10.1136/annrheumdis-2012-202753.

Article  PubMed  CAS  Google Scholar 

van Baarsen LG, Bos WH, Rustenburg F, van der Pouw Kraan TC, Wolbink GJ, Dijkmans BA, et al. Gene expression profiling in autoantibody-positive patients with arthralgia predicts development of arthritis. Arthritis Rheum. 2010;62(3):694–704. https://doi.org/10.1002/art.27294.

Article  PubMed  CAS  Google Scholar 

Macias-Segura N, Castaneda-Delgado JE, Bastian Y, Santiago-Algarra D, Castillo-Ortiz JD, Aleman-Navarro AL, et al. Transcriptional signature associated with early rheumatoid arthritis and healthy individuals at high risk to develop the disease. PLoS One. 2018;13(3):e0194205. https://doi.org/10.1371/journal.pone.0194205.

Article  PubMed  PubMed Central  CAS  Google Scholar 

• Brink M, Lundquist A, Alexeyenko A, Lejon K, Rantapaa-Dahlqvist S. Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis. Arthritis Res Ther. 2019;21(1):288. https://doi.org/10.1186/s13075-019-2066-9. This study confirmed the importance of IFN-α signalling in early RA using network enrichment analysis.

Chalan P, Bijzet J, van den Berg A, Kluiver J, Kroesen BJ, Boots AM, et al. Analysis of serum immune markers in seropositive and seronegative rheumatoid arthritis and in high-risk seropositive arthralgia patients. Sci Rep. 2016;6:26021. https://doi.org/10.1038/srep26021.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Castaneda-Delgado JE, Bastian-Hernandez Y, Macias-Segura N, Santiago-Algarra D, Castillo-Ortiz JD, Aleman-Navarro AL, et al. Type I interferon gene response is increased in early and established rheumatoid arthritis and correlates with autoantibody production. Front Immunol. 2017;8:285. https://doi.org/10.3389/fimmu.2017.00285.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cantaert T, van Baarsen LG, Wijbrandts CA, Thurlings RM, van de Sande MG, Bos C, et al. Type I interferons have no major influence on humoral autoimmunity in rheumatoid arthritis. Rheumatology (Oxford). 2010;49(1):156–66. https://doi.org/10.1093/rheumatology/kep345.

Article  PubMed  CAS  Google Scholar 

de Jong TD, Blits M, de Ridder S, Vosslamber S, Wolbink G, Nurmohamed MT, et al. Type I interferon response gene expression in established rheumatoid arthritis is not associated with clinical parameters. Arthritis Res Ther. 2016;18(1):290. https://doi.org/10.1186/s13075-016-1191-y.

Article  PubMed  PubMed Central  Google Scholar 

Reynolds JA, Briggs TA, Rice GI, Darmalinggam S, Bondet V, Bruce E, et al. Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles. Arthritis Res Ther. 2019;21(1):147. https://doi.org/10.1186/s13075-019-1929-4.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Plant D, Maciejewski M, Smith S, Nair N, Maximising therapeutic utility in rheumatoid arthritis consortium tRSG, Hyrich K, et al. Profiling of gene expression biomarkers as a classifier of methotrexate nonresponse in patients with rheumatoid arthritis. Arthritis Rheumatol. 2019;71(5):678–84. https://doi.org/10.1002/art.40810.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Back M, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42(34):3227–337. https://doi.org/10.1093/eurheartj/ehab484.

Article  PubMed  Google Scholar 

Hansildaar R, Vedder D, Baniaamam M, Tausche AK, Gerritsen M, Nurmohamed MT. Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout. Lancet Rheumatol. 2021;3(1):e58–70. https://doi.org/10.1016/S2665-9913(20)30221-6.

Article  PubMed  CAS  Google Scholar 

Ahmed D, Jaworski A, Roy D, Willmore W, Golshani A, Cassol E. Transcriptional profiling suggests extensive metabolic rewiring of human and mouse macrophages during early interferon alpha responses. Mediators Inflamm. 2018;2018:5906819. https://doi.org/10.1155/2018/5906819.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Thacker SG, Zhao W, Smith CK, Luo W, Wang H, Vivekanandan-Giri A, et al. Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis. Arthritis Rheum. 2012;64(9):2975–85. https://doi.org/10.1002/art.34504.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rodriguez-Carrio J, de Paz B, Lopez P, Prado C, Alperi-Lopez M, Ballina-Garcia FJ, et al. IFNalpha serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients. PLoS One. 2014;9(1):e86069. https://doi.org/10.1371/journal.pone.0086069.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rodriguez-Carrio J, Prado C, de Paz B, Lopez P, Gomez J, Alperi-Lopez M, et al. Circulating endothelial cells and their progenitors in systemic lupus erythematosus and early rheumatoid arthritis patients. Rheumatology (Oxford). 2012;51(10):1775–84. https://doi.org/10.1093/rheumatology/kes152.

Article  PubMed  CAS  Google Scholar 

Koivisto VA, Pelkonen R, Cantell K. Effect of interferon on glucose tolerance and insulin sensitivity. Diabetes. 1989;38(5):641–7. https://doi.org/10.2337/diab.38.5.641.

Article  PubMed