Gamma oscillations induced by optogenetic stimulation restore functional synaptic plasticity in a mouse model of stroke, according to new research. Twelve rounds of 40 Hz stimulation were applied to the interneurons of awake mice during the acute phase after experimentally induced stroke. The stimulated mice showed significant improvements in cerebral blood flow and motor function compared with non-stimulated mice. The improvements were associated with rescue of functional plasticity and increased neuronal survival, resulting in enhanced intraregional and interregional communication.