Clinical MedicineAutoimmunityDermatology Open Access | 10.1172/JCI166357

Dawoon Han,1 A Yeong Lee,1 Taehee Kim,1 Ji Young Choi,1 Mi Yeon Cho,1 Ahreum Song,1 Changhyeon Kim,2 Joon Ho Shim,3 Hyun Je Kim,4 Honesty Kim,5 Hillary Blaize D’Angio,5 Ryan Preska,5 Aaron T. Mayer,5 Miri Kim,6 Eun-Ji Choi,7 Tae-Gyun Kim,8 Eui-Cheol Shin,9 Kyemyung Park,10 Do-Young Kim,8 Soo-Chan Kim,11 and Jong Hoon Kim1

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Han, D. in: JCI | PubMed | Google Scholar

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Lee, A. in: JCI | PubMed | Google Scholar |

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Kim, T. in: JCI | PubMed | Google Scholar |

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Choi, J. in: JCI | PubMed | Google Scholar

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Cho, M. in: JCI | PubMed | Google Scholar |

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Song, A. in: JCI | PubMed | Google Scholar |

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Kim, C. in: JCI | PubMed | Google Scholar

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Shim, J. in: JCI | PubMed | Google Scholar |

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Kim, H. in: JCI | PubMed | Google Scholar |

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Kim, H. in: JCI | PubMed | Google Scholar

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by D’Angio, H. in: JCI | PubMed | Google Scholar |

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Preska, R. in: JCI | PubMed | Google Scholar

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

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1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Kim, M. in: JCI | PubMed | Google Scholar |

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Choi, E. in: JCI | PubMed | Google Scholar |

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Kim, T. in: JCI | PubMed | Google Scholar |

1Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

2Department of Computer Science and Engineering, College of Information and Biotechnology, National Institute of Science and Technology, Ulsan, South Korea.

3Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

4Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

5Enable Medicine, Menlo Park, California, USA.

6Yeouido St. Mary’s Hospital College of Medicine, The Catholic University of Korea, Seoul, South Korea.

7Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

8Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

9Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

10Graduate School of Health Science and Technology, College of Information and Biotechnology, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

11Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Address correspondence to: Jong Hoon Kim, Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul 06273, South Korea. Phone: 82.2.2019-3361; Email: jhkim074@yuhs.ac. Or to: Soo-Chan Kim, Department of Dermatology and Cutaneous Biology Research Institute, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, South Korea. Phone: 82.31.5189.8760; Email: kimsc@yuhs.ac. Or to: Do-Young Kim, Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. Phone: 82.2.2228.2084; Email: dykim@yuhs.ac.

Authorship note: DH, AYL, and TK contributed equally to this work.

Find articles by Shin, E. in: JCI | PubMed | Google Scholar |

1Department of Dermatology and Cutaneou