Pulte D, Brenner H. Changes in survival in head and neck cancers in the late 20th and early 21st century: a period analysis. Oncologist. 2010;15:994–1001. https://doi.org/10.1634/theoncologist.2009-0289.

Article  PubMed  PubMed Central  Google Scholar 

Osborn J, Radiography. W.B. Saunders Ltd. 73–6. https://doi.org/10.1016/j.radi.2016.08.008.

Gawryszuk A, Bijl HP, Holwerda M, Halmos GB, Wedman J, Witjes MJH, et al. Functional swallowing units (FSUs) as organs-at-risk for radiotherapy. PART 1: physiology and anatomy. Radiother Oncol. 2019;130:62–7. https://doi.org/10.1016/j.radonc.2018.10.028.

Article  PubMed  Google Scholar 

Okuni I, Otsubo Y, Ebihara S. Molecular and neural mechanism of Dysphagia due to Cancer. Int J Mol Sci. 2021;22. https://doi.org/10.3390/ijms22137033.

Feng FY, Kim HM, Lyden TH, Haxer MJ, Feng M, Worden FP, et al. Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys. 2007;68:1289–98. https://doi.org/10.1016/j.ijrobp.2007.02.049.

Article  PubMed  Google Scholar 

Petkar I, Rooney K, Roe JWG, Patterson JM, Bernstein D, Tyler JM, et al. DARS: a phase III randomised multicentre study of dysphagia- optimised intensity- modulated radiotherapy (Do-IMRT) versus standard intensity- modulated radiotherapy (S-IMRT) in head and neck cancer. BMC Cancer. 2016;16:770. https://doi.org/10.1186/s12885-016-2813-0.

Article  PubMed  PubMed Central  Google Scholar 

Ricchetti F, Wu B, McNutt T, Wong J, Forastiere A, Marur S, et al. Volumetric change of selected organs at risk during IMRT for oropharyngeal cancer. Int J Radiat Oncol Biol Phys. 2011;80:161–8. https://doi.org/10.1016/j.ijrobp.2010.01.071.

Article  PubMed  Google Scholar 

Christianen MEMC, Schilstra C, Beetz I, Muijs CT, Chouvalova O, Burlage FR, et al. Predictive modelling for swallowing dysfunction after primary (chemo)radiation: results of a prospective observational study. Radiother Oncol. 2012;105:107–14. https://doi.org/10.1016/j.radonc.2011.08.009.

Article  PubMed  Google Scholar 

Marks LB, Yorke ED, Jackson A, ten Haken RK, Constine LS, Eisbruch A, et al. Use of normal tissue complication probability models in the clinic. Int J Radiat Oncol Biol Phys. 2010;76:S10–9. https://doi.org/10.1016/j.ijrobp.2009.07.1754.

Article  PubMed  PubMed Central  Google Scholar 

Ursino S, Calistri E, De Felice F, Bonomo P, Desideri I, Franco P, et al. Patient-reported outcomes after swallowing (SWOARs)-Sparing IMRT in Head and Neck cancers: primary results from a prospective study endorsed by the Head and Neck Study Group (HNSG) of the Italian Association of Radiotherapy and Clinical Oncology (AIRO). Dysphagia Springer. 2023;38:159–70. https://doi.org/10.1007/s00455-022-10434-4.

Article  Google Scholar 

Dale T, Hutcheson K, Mohamed ASR, Lewin JS, Gunn GB, Rao AUK, et al. Beyond mean pharyngeal constrictor dose for beam path toxicity in non-target swallowing muscles: dose–volume correlates of chronic radiation-associated dysphagia (RAD) after oropharyngeal intensity modulated radiotherapy. Radiother Oncol. 2016;118:304–14. https://doi.org/10.1016/j.radonc.2016.01.019.

Article  Google Scholar 

Hutcheson KA, Nurgalieva Z, Zhao H, Gunn GB, Giordano SH, Bhayani MK et al. (2019) Two-year prevalence of dysphagia and related outcomes in head and neck cancer survivors: An updated SEER-Medicare analysis. Head and Neck. John Wiley & Sons, Ltd. 41:479–87. https://doi.org/10.1002/hed.25412.

Nevens D, Goeleven A, Duprez F, Laenen A, Dejaeger E, De Neve W, et al. Correlation of patient- and physician-scored Dysphagia with videofluoroscopies in patients treated with Radiotherapy for Head and Neck Cancer. Dysphagia Springer New York LLC. 2018;33:684–90. https://doi.org/10.1007/s00455-018-9888-5.

Article  CAS  Google Scholar 

Wishart LR, Harris GB, Cassim N, Alimin S, Liao T, Brown B, et al. Association between objective ratings of swallowing and Dysphagia-Specific Quality of Life in patients receiving (Chemo)radiotherapy for Oropharyngeal Cancer. Dysphagia Springer. 2022;37:1014–21. https://doi.org/10.1007/s00455-021-10364-7.

Article  Google Scholar 

Goepfert RP, Lewin JS, Barrow MP, Gunn GB, Fuller CD, Beadle BM, et al. Long-Term, prospective performance of the MD Anderson Dysphagia Inventory in Low-Intermediate Risk Oropharyngeal Carcinoma after Intensity Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys. 2017;97:700–8. https://doi.org/10.1016/j.ijrobp.2016.06.010.

Article  PubMed  Google Scholar 

Chen A, Frankowski R, Bishop-Leone J, Hebert T, Leyk S, Lewin J, et al. The Development and Validation of a Dysphagia-Specific Quality-of-life questionnaire for patients with Head and Neck Cancer: the M. D. Anderson Dysphagia Inventory. Archives Otolaryngology–Head Neck Surg. 2001;127:870–6. https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/482382.

CAS  Google Scholar 

Grant S, Kamal M, Mohamed ASR, Zaveri J, Barrow MP, Gunn GB, et al. Single-item discrimination of quality-of-life-altering dysphagia among 714 long-term oropharyngeal cancer survivors: comparison of patient-reported outcome measures of swallowing. Cancer. 2019;125:1654–64. https://doi.org/10.1002/cncr.31957.

Article  CAS  PubMed  Google Scholar 

Kumarasiri A, Siddiqui F, Liu C, Yechieli R, Shah M, Pradhan D et al. (2014) Deformable image registration based automatic CT-to-CT contour propagation for head and neck adaptive radiotherapy in the routine clinical setting. Medical Physics. AAPM - American Association of Physicists in Medicine. 41:121712. https://doi.org/10.1118/1.4901409.

Weppler S, Schinkel C, Kirkby C, Smith W. Lasso logistic regression to derive workflow-specific algorithm performance requirements as demonstrated for head and neck cancer deformable image registration in adaptive radiation therapy. Phys Med Biol. 2020;65:195013. https://doi.org/10.1088/1361-6560/ab9fc8.

Article  PubMed  Google Scholar 

Hinther A, Samson N, Lau H, Quon H, Banerjee R, Lysack JT, et al. Volumetric changes in pharyngeal structures following head and neck cancer chemoradiation therapy. Laryngoscope. 2020;130:597–602. https://doi.org/10.1002/lary.28164.

Article  PubMed  Google Scholar 

Kumarasiri A, Liu C, Kamal M, Fraser C, Brown S, Chetty IJ, et al. Changes in pharyngeal constrictor volumes during head and neck radiation therapy: implications for dose delivery. J Cancer Res Ther. 2017;13:218–23. https://doi.org/10.4103/0973-1482.183176.

Article  CAS  PubMed  Google Scholar 

Eisbruch A, Schwartz M, Rasch C, Vineberg K, Damen E, van As CJ, et al. Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: which anatomic structures are affected and can they be spared by IMRT? Int J Radiat Oncol Biol Phys. 2004;60:1425–39. https://doi.org/10.1016/j.ijrobp.2004.05.050.

Article  PubMed  Google Scholar 

Popovtzer A, Cao Y, Feng FY, Eisbruch A. Anatomical changes in the pharyngeal constrictors after chemo-irradiation of head and neck cancer and their dose-effect relationships: MRI-based study. Radiother Oncol. 2009;93:510–5. https://doi.org/10.1016/j.radonc.2009.05.013.

Article  PubMed  PubMed Central  Google Scholar 

Bentzen SM, Constine LS, Deasy JO, Eisbruch A, Jackson A, Marks LB, et al. Quantitative analyses of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues. Int J Radiat Oncol Biol Phys. 2010;76:S3–9. https://doi.org/10.1016/j.ijrobp.2009.09.040.

Article  PubMed  PubMed Central  Google Scholar 

Duffy O, Forde E, Leech M. The dilemma of parotid gland and pharyngeal constrictor muscles preservation-Is daily online image guidance required? A dosimetric analysis. Med Dosim. 2017;42:24–30. https://doi.org/10.1016/j.meddos.2016.10.003.

Article  PubMed  Google Scholar 

Meheissen MAM, Mohamed ASR, Kamal M, Hernandez M, Volpe S, Elhalawani H, et al. A prospective longitudinal assessment of MRI signal intensity kinetics of non-target muscles in patients with advanced stage oropharyngeal cancer in relationship to radiotherapy dose and post-treatment radiation-associated dysphagia: preliminary findings. Radiother Oncol. 2019;130:46–55. https://doi.org/10.1016/j.radonc.2018.08.010.

Article  Google Scholar 

Tsai CJ, Jackson A, Setton J, Riaz N, McBride S, Leeman J, et al. Modeling dose response for late Dysphagia in patients with Head and Neck Cancer in the modern era of definitive chemoradiation. JCO Clin Cancer Inf. 2017;1:1–7. https://doi.org/10.1200/CCI.17.00070.

Article  Google Scholar 

Eisbruch A, Kim HM, Feng FY, Lyden TH, Haxer MJ, Feng M, et al. Chemo-IMRT of oropharyngeal cancer aiming to reduce dysphagia: swallowing organs late complication probabilities and dosimetric correlates. Int J Radiat Oncol Biol Phys. 2011;81:e93–9. https://doi.org/10.1016/j.ijrobp.2010.12.067.

Article  PubMed  PubMed Central  Google Scholar 

Hutchison AR, Wishart LR, Brown B, Ward EC, Hargrave C, Brown E, et al. Exploring the interplay between Radiotherapy Dose and physiological changes in the swallowing mechanism in patients undergoing (Chemo)radiotherapy for Oropharynx Cancer. Dysphagia Springer. 2022;37:567–77. https://doi.org/10.1007/s00455-021-10307-2.

Article  Google Scholar 

Jin X, Hu W, Shang H, Han C, Yi J, Zhou Y, et al. CBCT-based volumetric and dosimetric variation evaluation of volumetric modulated arc radiotherapy in the treatment of nasopharyngeal cancer patients. Radiation Oncol BioMed Cent. 2013;8:279. https://doi.org/10.1186/1748-717X-8-279.

Article  Google Scholar 

Hutcheson KA, Barrow MP, Lisec A, Barringer DA, Gries K, Lewin JS. What is a clinically relevant difference in MDADI scores between groups of head and neck cancer patients? Laryngoscope. 2016;126:1108–13. https://doi.org/10.1002/lary.25778.

Article  PubMed  Google Scholar 

Andersen ES, Noe KØ, Sørensen TS, Nielsen SK, Fokdal L, Paludan M, et al. Simple DVH parameter addition as compared to deformable registration for bladder dose accumulation in cervix cancer brachytherapy. Radiotherapy Oncol Elsevier. 2013;107:52–7. https://doi.org/10.1016/j.radonc.2013.01.013.

Article  Google Scholar 

Weppler S, Quon H, Schinkel C, Ddamba J, Harjai N, Vigal C, et al. Determining clinical patient selection guidelines for Head and Neck Adaptive Radiation Therapy using Random Forest Modelling and a Novel Simplification Heuristic. Front Oncol Front. 2021;0:1889. https://doi.org/10.3389/FONC.2021.650335.

Article  Google Scholar 

Harris CR, Millman KJ, van der Walt SJ, Gommers R, Virtanen P, Cournapeau D et al. (2020) Array programming with NumPy. Nature. Nature Research. p. 357–62. https://doi.org/10.1038/s41586-020-2649-2.

Yaniv Z, Lowekamp BC, Johnson HJ, Beare R. SimpleITK Image-Analysis notebooks: a Collaborative Environment for Education and Reproducible Research. Journal of Digital Imaging. Springer New York LLC. 2018;31:290–303. https://doi.org/10.1007/s10278-017-0037-8.

Article  Google Scholar 

Ranganathan P, Pramesh CS, Buyse M. Common pitfalls in statistical analysis: the perils of multiple testing. Perspect Clin Res. 2016;7. https://doi.org/10.4103/2229-3485.179436.

Langendijk JA, Doornaert P, Rietveld DHF, Verdonck-de Leeuw IM, René Leemans C, Slotman BJ. A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer. Radiother Oncol. 2009;90:189–95. https://doi.org/10.1016/j.radonc.2008.12.017.

Article  PubMed  Google Scholar